Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.56 |
| ▸ | CTSK | P43235 | 2/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.54 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.54 |
| ▸ | KLK7 | P49862 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.51 |
| ▸ | CCKAR | P32238 | 1/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27427437 | 1.00 | CTSS (0.56) | CTSSCTSKCTSLCTSBSCN9A | |
| SCHEMBL27406188 | 0.86 | CTSS (0.53) | CTSSCTSKCTSLCTSBSCN9A | |
| SCHEMBL7518449 | 0.86 | CTSS (0.53) | CTSSCTSKCTSLCTSBSCN9A | |
| SCHEMBL8812581 | 0.85 | CTSK (0.60) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL8812573 | 0.85 | CTSK (0.60) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL8809633 | 0.81 | CAPN1 (0.56) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL8809618 | 0.81 | CAPN1 (0.56) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL8810112 | 0.81 | CAPN1 (0.51) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL8810100 | 0.81 | CAPN1 (0.51) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL27424651 | 0.80 | CTSS (0.57) | CTSSCTSKCTSLCTSBSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | claimed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | claimed |
| JP-8104685-A | — | — | None | — | — | JP | disclosed |
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| JP-H08104685-A | LACTOL DERIVATIVE, ITS PRODUCTION AND USE | TAKEDA CHEM IND LTD | 1996-04-23 | — | — | JP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| CN-1106001-A | Lactol derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-02 | — | — | CN | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |