Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | CTSK | P43235 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | CCKAR | P32238 | 1/20 | 0.47 |
| ▸ | CCKBR | P32239 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27406188 | 1.00 | CTSS (0.53) | CTSSCTSKCTSLCTSBSCN9A | |
| SCHEMBL7514113 | 0.88 | CTSK (0.59) | CTSSCTSKCTSLCTSB | |
| SCHEMBL27427437 | 0.86 | CTSS (0.56) | CTSSCTSKCTSLCTSBSCN9A | |
| SCHEMBL7516532 | 0.86 | CTSS (0.56) | CTSSCTSKCTSLCTSBSCN9A | |
| SCHEMBL8812311 | 0.82 | CAPN1 (0.51) | CTSSCTSKCTSLCTSB | |
| SCHEMBL8812325 | 0.82 | CAPN1 (0.51) | CTSSCTSKCTSLCTSB | |
| SCHEMBL8406499 | 0.79 | CTSK (0.62) | CTSSCTSKCTSLCTSB | |
| SCHEMBL3577128 | 0.79 | CTSK (0.62) | CTSSCTSKCTSLCTSB | |
| SCHEMBL7517799 | 0.79 | BMP1 (0.47) | CTSSCTSKCTSLCTSBKLK5 | |
| SCHEMBL7513070 | 0.79 | SCN9A (0.61) | CTSSCTSKCTSLCTSBSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| CN-1106001-A | Lactol derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-02 | — | — | CN | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |