Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ILK | Q13418 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | FHIT | P49789 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794327 | 0.81 | TSHR (0.61) | TSHRILKALDH1A1MAPTHPGD | |
| SCHEMBL13343520 | 0.79 | NPSR1 (0.46) | TSHRILKALDH1A1MAPTHPGD | |
| SCHEMBL9296047 | 0.79 | TSHR (0.58) | TSHRILKALDH1A1MAPTHPGD | |
| SCHEMBL9750563 | 0.79 | TSHR (0.58) | TSHRILKALDH1A1MAPTHPGD | |
| SCHEMBL20027965 | 0.79 | TSHR (0.58) | TSHRILKALDH1A1MAPTHPGD | |
| SCHEMBL9332640 | 0.76 | TSHR (0.55) | TSHRILKALDH1A1MAPTGAA | |
| SCHEMBL9332630 | 0.75 | TSHR (0.54) | TSHRILKALDH1A1MAPTHPGD | |
| SCHEMBL31299616 | 0.74 | TSHR (0.53) | TSHRILKALDH1A1MAPTHPGD | |
| SCHEMBL7794805 | 0.73 | TSHR (0.78) | TSHRILKALDH1A1MAPTHPGD | |
| SCHEMBL28802104 | 0.73 | TSHR (0.52) | TSHRILKALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12590087-B2 | Inhibiting USP36 | VALO HEALTH, INC. (US) | 2026-03-31 | — | — | US | disclosed |
| US-20250295652-A1 | Inhibitors of Molluscum Contagiosum Infection and Methods Using the Same | UNIV PENNSYLVANIA (US) | 2025-09-25 | — | — | US | disclosed |
| CN-114222574-B | Inhibition of USP36 | 瓦洛健康股份有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-118541359-A | Inhibitors of molluscum contagiosum infection and methods of use thereof | 宾夕法尼亚大学董事会 | 2024-08-23 | — | — | CN | disclosed |
| US-20220213088-A1 | INHIBITING USP36 | Valo Health, LLC | 2022-07-07 | — | — | US | disclosed |
| US-20220213088-A1 | INHIBITING USP36 | Valo Health, LLC | 2022-07-07 | — | — | US | disclosed |
| CN-114222574-A | Inhibition of USP36 | 瓦洛健康股份有限公司 | 2022-03-22 | — | — | CN | disclosed |
| EP-3962486-A1 | INHIBITING USP36 | Valo Health, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020223548-A1 | INHIBITING USP36 | INTEGRAL EARLY DISCOVERY, INC. (US) | 2020-11-05 | — | — | WO | disclosed |
| WO-2020223548-A1 | INHIBITING USP36 | INTEGRAL EARLY DISCOVERY, INC. (US) | 2020-11-05 | — | — | WO | disclosed |
| EP-2580207-B1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2017-09-27 | — | — | EP | disclosed |
| US-8703768-B2 | Nitrogen containing heteroaryl compounds | HOFFMANN-LA ROCHE INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-8623866-B2 | — | — | 2014-01-07 | — | — | US | disclosed |
| EP-2580207-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011154327-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-15 | — | — | WO | disclosed |
| US-20110306589-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-15 | — | — | US | disclosed |
| CN-101973959-A | 4-methyl-1,2,3-thiadiazole-5-formyl urea compounds and preparation method and application thereof | LIER CHEMICAL CO LTD | 2011-02-16 | — | — | CN | disclosed |
| US-4142046-A | BACTERICIDES, 7-AMINO-CEPHALOSPORINS | SMITHKLINE CORPORATION (US) | 1979-02-27 | — | — | US | disclosed |
| US-4060610-A | Pharmaceutical compositions comprising 7-acyl-3-(substituted triazolyl thiomethyl)-cephalosporins and methods of treating bacterial infections | SMITHKLINE CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |
| US-3989694-A | ANTIBACTERIAL | SMITHKLINE CORPORATION (US) | 1976-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250295652-A1 | Inhibitors of Molluscum Contagiosum Infection and Methods Using the Same | ITCH, EIF2AK2, TBK1 | TSHR 4881/4885ILK 177/4885ALDH1A1 3761/4885 |
| US-20110306589-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | PDE10A, PDE3A, PDE2A | TSHR 1037/4885ILK 4369/4885ALDH1A1 271/4885 |
| US-20220213088-A1 | INHIBITING USP36 | USP36, USP30, USP39 | TSHR 3984/4885ILK 4247/4885ALDH1A1 1508/4885 |
| US-12590087-B2 | Inhibiting USP36 | USP36, USP39, USP30 | TSHR 871/4885ILK 4096/4885ALDH1A1 1869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.