Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521329 | 0.81 | PIK3CG (0.39) | L3MBTL1MAPTPIK3CAPIK3CGPIK3CD | |
| SCHEMBL2760410 | 0.78 | MAPT (0.47) | L3MBTL1MAPTPOLBMITFSMN1; SMN2 | |
| SCHEMBL20555214 | 0.72 | ALDH1A1 (0.38) | L3MBTL1MAPTPOLBMITFLMNA | |
| SCHEMBL7514334 | 0.70 | L3MBTL1 (0.69) | L3MBTL1MAPTPOLBMITFNPC1 | |
| SCHEMBL1095937 | 0.69 | — | — | |
| SCHEMBL28805566 | 0.69 | MAPT (0.36) | L3MBTL1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL20555201 | 0.68 | ALDH1A1 (0.33) | MAPTPOLBLMNAKMT2A | |
| SCHEMBL20555297 | 0.66 | LRRK2 (0.36) | L3MBTL1MAPTPOLBLMNA | |
| SCHEMBL15528397 | 0.66 | ALDH1A1 (0.35) | L3MBTL1MAPTPOLBLMNAKMT2A | |
| SCHEMBL1559636 | 0.65 | ALDH1A1 (0.43) | L3MBTL1MAPTPOLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2580207-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011154327-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-15 | — | — | WO | disclosed |