Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Lucanthone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.90 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.90 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.90 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.90 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.90 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.90 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.90 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.90 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.90 |
| ▸ | APP | P05067 | 6/20 | 0.90 |
| ▸ | MAPT | P10636 | 5/20 | 0.90 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.90 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.90 |
| ▸ | APEX1 | P27695 | 2/20 | 0.90 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.90 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.90 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.90 |
| ▸ | MAOA | P21397 | 1/20 | 0.90 |
| ▸ | RAD52 | P43351 | 3/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lucanthone SCHEMBL9156 | 0.95 | APP (1.00) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL29422254 | 0.95 | APP (1.00) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL30572937 | 0.95 | APP (1.00) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL28172520 | 0.94 | APP (0.98) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL29503548 | 0.94 | APP (0.98) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL419165 | 0.94 | APP (0.98) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL8004521 | 0.94 | APP (0.98) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL1650327 | 0.93 | APP (0.96) | APPMAPTCHRM2HTR1AADRA2A | |
| SCHEMBL13856933 | 0.90 | APP (0.86) | APPMAPTCHRM2HTR1AADRA2A | |
| Hycanthone SCHEMBL1152656 | 0.89 | MAPT (0.92) | APPMAPTCHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000050031-A9 | CO-ADMINISTRATION OF LUCANTHONE AND RADIATION FOR TREATMENT OF CANCER | BASES ROBERT (US) | 2002-06-20 | — | — | WO | disclosed |
| US-6391911-B1 | Coadministration of lucanthone and radiation for treatment of cancer | BASES ROBERT E (US) | 2002-05-21 | — | — | US | disclosed |
| WO-2000050031-A1 | CO-ADMINISTRATION OF LUCANTHONE AND RADIATION FOR TREATMENT OF CANCER | BASES ROBERT (US) | 2000-08-31 | — | — | WO | disclosed |