Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Lucanthone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.98 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.98 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.98 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.98 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.98 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.98 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.98 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.98 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.98 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.98 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.98 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.98 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.98 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.98 |
| ▸ | TOP2A known ✓ | P11388 | 6/20 | 0.74 |
| ▸ | TOP2B known ✓ | Q02880 | 6/20 | 0.74 |
| ▸ | BCHE known ✓ | P06276 | 2/20 | 0.54 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 7/20 | 0.98 |
| ▸ | MAPT | P10636 | 6/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lucanthone SCHEMBL29503548 | 1.00 | APP (0.98) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL28172520 | 1.00 | APP (0.98) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL8004521 | 1.00 | APP (0.98) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL30572937 | 0.99 | APP (1.00) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL29422254 | 0.99 | APP (1.00) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL9156 | 0.99 | APP (1.00) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL1650327 | 0.97 | APP (0.96) | APPMAPTCHRM2HTR1AADRA2A | |
| Lucanthone SCHEMBL7517404 | 0.94 | APP (0.90) | APPMAPTCHRM2HTR1AADRA2A | |
| SCHEMBL13856933 | 0.92 | APP (0.86) | APPMAPTCHRM2HTR1AADRA2A | |
| Becanthone SCHEMBL637068 | 0.91 | APP (0.81) | APPMAPTCHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4474 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109862790-A | Water soluble controlled release compositions and methods of making and using the same | 海怡弥私人有限公司 | 2019-06-07 | — | — | CN | claimed |
| EP-3078664-B1 | ANTIPARASITIC DIHYDROAZOLE COMPOSITIONS | MERIAL INC (US) | 2019-02-20 | — | — | EP | claimed |
| CN-106727581-A | The anti parasitic purposes of one class alkamine compound | 中国疾病预防控制中心寄生虫病预防控制所 | 2017-05-31 | — | — | CN | claimed |
| CN-103261217-B | Soluble pd-1 variants, fusion constructs, and uses thereof | 港大科桥有限公司 | 2017-04-26 | — | — | CN | claimed |
| CN-106573918-A | Azepanyl derivatives having antiparasitic activity and pharmaceutical compositions containing them | 默克专利股份有限公司 | 2017-04-19 | — | — | CN | claimed |
| CN-104583212-B | pyrimidinone derivatives as antimalarial agents | 赛诺菲 | 2017-04-19 | — | — | CN | claimed |
| CN-106573052-A | Anti-PD-1 antibodies | 中美冠科生物技术（太仓）有限公司 | 2017-04-19 | — | — | CN | claimed |
| CN-106565673-A | 5-fluoropyrimidine heterocyclic compound with Wnt signal channel inhibition activity and application thereof | 苏州云轩医药科技有限公司 | 2017-04-19 | — | — | CN | claimed |
| CN-106554968-A | Schistosoma japonicum recombiant protein and its preparation method and application | 中国农业科学院上海兽医研究所 | 2017-04-05 | — | — | CN | claimed |
| CN-106480223-A | A kind of method of detection schistosomicide DNA | 江苏省血吸虫病防治研究所 | 2017-03-08 | — | — | CN | claimed |
| EP-0507629-A1 | Sustained release capsule and formulations for insertion into rumen | ELI LILLY AND COMPANY (US) | 1992-10-07 | — | — | EP | claimed |
| EP-0110298-B1 | ACRIDANONE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-06-01 | — | — | EP | claimed |
| CN-87106696-A | Protein and preparation method thereof, the order of ADN, antibody and uses thereof, poxvirus du is transformed or the cell that infects is used to prevent the medicament composition of schistosomicide, and as the purposes of the developer of glutathione-s-transferase activity | — | 1988-04-27 | — | — | CN | claimed |
| EP-0111205-B1 | ACRIDANONE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-04-01 | — | — | EP | claimed |
| EP-0059386-B1 | IMIDAZODIAZEPINES, INTERMEDIATE PRODUCTS AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-09-18 | — | — | EP | claimed |
| EP-0059388-B1 | IMIDAZODIAZEPINES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-29 | — | — | EP | claimed |
| EP-0059390-B1 | IMIDAZODIAZEPINES, INTERMEDIATE PRODUCTS AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-29 | — | — | EP | claimed |
| EP-0059387-B1 | IMIDAZODIAZEPINES, PROCESS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | claimed |
| EP-0059389-B1 | IMIDAZODIAZEPINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-12-12 | — | — | EP | claimed |
| US-4046890-A | ENANTIOMORPHS, ANTHELMINTHIC, SEDATIVES, ANTI-CONVULSANTS, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1977-09-06 | — | — | US | claimed |