SCHEMBL7517643

SCHEMBL7517643

CCOC(=O)c1c[nH]c2c(C3CC3)c(Br)c(F)cc2c1=O

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2C19 P33261 1/20 0.54
GABRA1 P14867 3/20 0.49
GABRB2 P47870 3/20 0.49
GABRB1 P18505 2/20 0.49
GABRA3 P34903 2/20 0.49
CLEC4M Q9H2X3 1/20 0.49
KDM4E B2RXH2 3/20 0.47
MAPT P10636 2/20 0.46
KMT2A Q03164 4/20 0.42
MEN1 O00255 2/20 0.42
ALDH1A1 P00352 2/20 0.39
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39
HSD17B10 Q99714 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9487698 0.89 CYP1A2 (0.56) CYP1A2CYP3A4CYP2C19GABRA1GABRB2
SCHEMBL10519082 0.84 CYP1A2 (0.60) CYP1A2CYP3A4CYP2C19GABRA1GABRB2
SCHEMBL6903795 0.81 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C19GABRA1GABRB2
SCHEMBL29376920 0.79 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C19GABRA1GABRB2
SCHEMBL9635290 0.79 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C19GABRA1GABRB2
SCHEMBL7509482 0.78 CYP1A2 (0.53) CYP1A2CYP3A4CYP2C19GABRA1GABRB2
SCHEMBL4765666 0.77 CYP1A2 (0.55) CYP1A2CYP3A4CYP2C19GABRA1GABRB2
SCHEMBL11235716 0.77 CYP1A2 (0.63) CYP1A2CYP3A4CYP2C19GABRA1GABRB2
SCHEMBL7509600 0.77 CYP1A2 (0.49) CYP1A2CYP3A4CYP2C19GABRA1GABRB2
SCHEMBL25208357 0.76 CLEC4M (0.63) CYP1A2CYP3A4CYP2C19GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1226146-A2 QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS ABBOTT LABORATORIES (US) 2002-07-31 EP disclosed
WO-2001032655-A2 QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS ABBOTT LABORATORIES (US) 2001-05-10 WO disclosed
EP-0700399-A1 36-DERIVATIVES OF RIFAMYCINS AND THEIR USE AS ANTIMICROBIAL AGENTS GRUPPO LEPETIT S.P.A. (IT) 1996-03-13 EP disclosed
WO-1994028002-A1 36-DERIVATIVES OF RIFAMYCINS AND THEIR USE AS ANTIMICROBIAL AGENTS GRUPPO LEPETIT S.P.A. (IT) 1994-12-08 WO disclosed