Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813105 | 0.79 | MAPT (0.44) | ESR1ESR2ALOX12ALDH1A1HPGD | |
| SCHEMBL1270651 | 0.78 | ESR1 (0.42) | ESR1ESR2ALOX12ALDH1A1MAPT | |
| SCHEMBL9225762 | 0.78 | ESR1 (0.42) | ESR1ESR2ALOX12ALDH1A1MAPT | |
| SCHEMBL12191013 | 0.76 | ESR1 (0.41) | ESR1ESR2ALOX12ALDH1A1HPGD | |
| SCHEMBL9358655 | 0.75 | ACHE (0.36) | LMNATSHRACHE | |
| SCHEMBL3454933 | 0.75 | MAPT (0.37) | ESR1ESR2MAPTNR1H2NR1H3 | |
| SCHEMBL10427763 | 0.74 | NR1H2 (0.41) | ESR1ESR2ALOX12ALDH1A1ALOX15 | |
| SCHEMBL9339400 | 0.74 | ESR1 (0.39) | ESR1ESR2MAPTNR1H2NR1H3 | |
| SCHEMBL386730 | 0.74 | ESR1 (0.39) | ESR1ESR2ALOX12MAPTNR1H2 | |
| SCHEMBL1270667 | 0.74 | ESR1 (0.39) | ESR1ESR2ALOX12ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |