Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CAPNS1 | P04632 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7518851 | 0.91 | PSMB5 (0.48) | CAPN1CTSKCTSLCTSBCTSS | |
| SCHEMBL7514127 | 0.91 | PSMB5 (0.48) | CAPN1CTSKCTSLCTSBCTSS | |
| SCHEMBL7518132 | 0.87 | CAPN1 (0.57) | CAPN1CTSKCTSLCTSBCTSS | |
| SCHEMBL7515061 | 0.86 | CTSK (0.59) | CAPN1CTSKCTSLCTSBCTSS | |
| SCHEMBL7510915 | 0.84 | CAPN1 (0.46) | CAPN1CTSKCTSLCTSBCTSS | |
| SCHEMBL7516164 | 0.78 | CAPN1 (0.60) | CAPN1CTSKCTSLCTSBCTSS | |
| SCHEMBL7516176 | 0.78 | CAPN1 (0.60) | CAPN1CTSKCTSLCTSBCTSS | |
| SCHEMBL23722728 | 0.76 | HDAC8 (0.56) | KDM4EMEN1MAPTKMT2APOLB | |
| SCHEMBL7517242 | 0.76 | CAPN1 (0.58) | CAPN1CTSKCTSLCTSBCTSS | |
| SCHEMBL7514777 | 0.76 | CAPN1 (0.58) | CAPN1CTSKCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | claimed |
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |