Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.59 |
| ▸ | CTSL | P07711 | 2/20 | 0.59 |
| ▸ | CTSB | P07858 | 2/20 | 0.59 |
| ▸ | CTSS | P25774 | 2/20 | 0.59 |
| ▸ | CAPN1 | P07384 | 8/20 | 0.58 |
| ▸ | CAPNS1 | P04632 | 2/20 | 0.57 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510915 | 0.89 | CAPN1 (0.46) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7517851 | 0.87 | CTSK (0.63) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7517814 | 0.86 | CAPN1 (0.43) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7514127 | 0.85 | PSMB5 (0.48) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7518851 | 0.85 | PSMB5 (0.48) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL7513532 | 0.85 | CAPN1 (0.61) | CTSKCAPN1CAPNS1CASP1CASP3 | |
| SCHEMBL8808938 | 0.82 | CAPN1 (0.62) | CAPN1CAPNS1CASP1HTTCCR1 | |
| SCHEMBL8808955 | 0.82 | CAPN1 (0.62) | CAPN1CAPNS1CASP1HTTCCR1 | |
| SCHEMBL8407942 | 0.81 | CAPN1 (0.61) | CTSKCAPN1CAPNS1CASP1CASP3 | |
| SCHEMBL8407953 | 0.81 | CAPN1 (0.61) | CTSKCAPN1CAPNS1CASP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | claimed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | claimed |
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |