SCHEMBL7518685

SCHEMBL7518685

CSC1CCc2ccccc2C1=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 4/20 0.49
ACHE P22303 2/20 0.47
KDM4E B2RXH2 2/20 0.46
CES1 P23141 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
DRD2 P14416 2/20 0.43
HTR2A P28223 2/20 0.43
HTR2C P28335 2/20 0.43
HTR2B P41595 2/20 0.43
SIGMAR1 Q99720 2/20 0.43
PTGS1 P23219 1/20 0.43
PTGS2 P35354 1/20 0.43
ALDH1A1 P00352 1/20 0.42
MAPT P10636 1/20 0.42
TSHR P16473 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7147610 0.81 ACHE (0.60) CYP19A1ACHEALDH1A1MAPTTSHR
SCHEMBL5285462 0.79 DDB1 (0.53) CYP19A1ACHEKDM4ECES1SMN1; SMN2
SCHEMBL16863989 0.77 SIGMAR1 (0.43) CYP19A1ACHEKDM4ESMN1; SMN2NPC1
SCHEMBL25001243 0.77 ACHE (0.66) CYP19A1ACHEKDM4ECES1SMN1; SMN2
SCHEMBL10000875 0.77 ACHE (0.66) CYP19A1ACHEKDM4ECES1SMN1; SMN2
SCHEMBL12676173 0.77 ACHE (0.66) CYP19A1ACHEKDM4ECES1SMN1; SMN2
SCHEMBL677613 0.77 ACHE (0.66) CYP19A1ACHEKDM4ECES1SMN1; SMN2
SCHEMBL13039620 0.76 DRD2 (0.56) CYP19A1ACHECES1DRD2HTR2A
SCHEMBL14463214 0.76 CYP19A1 (0.42) CYP19A1ACHEKDM4ESMN1; SMN2NPC1
SCHEMBL7147602 0.76 CYP24A1 (0.56) CYP19A1DRD2HTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6111110-A Synthesis of benzo[f]quinolinones ELI LILLY AND COMPANY (US) 2000-08-29 US claimed
EP-0969003-A2 Process for the preparation of benzo[f]quinolinone derivatives and intermediates ELI LILLY AND COMPANY (US) 2000-01-05 EP claimed
WO-1999065878-A1 SYNTHESIS OF BENZO[F]QUINOLINONES ELI LILLY AND COMPANY (US) 1999-12-23 WO claimed
WO-1998018757-A1 SYNTHESIS OF BENZO[F]QUINOLINONES ELI LILLY AND COMPANY (US) 1998-05-07 WO claimed
EP-0839807-A1 Synthesis of benzo(f)quinolinones ELI LILLY AND COMPANY (US) 1998-05-06 EP claimed
US-7214465-B2 Positive photosensitive composition FUJIFILM CORPORATION (JP) 2007-05-08 US disclosed
EP-0856001-B1 PYRIMIDINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2002-08-28 EP disclosed
US-6111110-A Synthesis of benzo[f]quinolinones ELI LILLY AND COMPANY (US) 2000-08-29 US disclosed
EP-0969003-A2 Process for the preparation of benzo[f]quinolinone derivatives and intermediates ELI LILLY AND COMPANY (US) 2000-01-05 EP disclosed
WO-1999065878-A1 SYNTHESIS OF BENZO[F]QUINOLINONES ELI LILLY AND COMPANY (US) 1999-12-23 WO disclosed
EP-0856001-A1 PYRIMIDINE DERIVATIVES AS 5HT 2C?-RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1998-08-05 EP disclosed
US-5753663-A 5HT2C ANTAGONIST, USEFUL FOR TREATING ANXIETY, PAIN, OBSESSIVE COMPULSIVE DISORDER, ALCOHOLISM, DEPRESSION, MIGRAINE, SLEEP DISORDER, ANOREXIA NERVOSA AND PRIAPISM SYNTEX (U.S.A.) INC. (US) 1998-05-19 US disclosed
WO-1998018757-A1 SYNTHESIS OF BENZO[F]QUINOLINONES ELI LILLY AND COMPANY (US) 1998-05-07 WO disclosed
EP-0839807-A1 Synthesis of benzo(f)quinolinones ELI LILLY AND COMPANY (US) 1998-05-06 EP disclosed
WO-1997012880-A1 PYRIMIDINE DERIVATIVES AS 5HT2C-RECEPTOR ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 1997-04-10 WO disclosed