Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.57 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7130861 | 0.89 | DRD2 (0.69) | DRD2NR1H2NR1H3SIGMAR1DRD3 | |
| SCHEMBL7130854 | 0.89 | DRD2 (0.69) | DRD2NR1H2NR1H3SIGMAR1DRD3 | |
| SCHEMBL7130859 | 0.89 | DRD2 (0.69) | DRD2NR1H2NR1H3SIGMAR1DRD3 | |
| SCHEMBL7141126 | 0.85 | SIGMAR1 (0.48) | SIGMAR1SCN4A | |
| SCHEMBL7141118 | 0.85 | SIGMAR1 (0.48) | SIGMAR1SCN4A | |
| SCHEMBL7518870 | 0.82 | DRD2 (0.60) | DRD2NR1H2NR1H3SIGMAR1DRD3 | |
| SCHEMBL7137397 | 0.75 | DRD2 (0.68) | DRD2SIGMAR1DRD3 | |
| SCHEMBL7137390 | 0.75 | DRD2 (0.68) | DRD2SIGMAR1DRD3 | |
| SCHEMBL7137393 | 0.75 | DRD2 (0.68) | DRD2SIGMAR1DRD3 | |
| SCHEMBL13406114 | 0.74 | ACHE (0.58) | DRD2SIGMAR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240141-A1 | NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. Carlsson Research AB (SE) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001046144-A1 | NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2001-06-28 | — | — | WO | disclosed |