Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL750002 | 0.99 | DHODH (0.33) | DHODHALDH1A1LMNAMAPTHPGD | |
| SCHEMBL746629 | 0.93 | WDR5 (0.33) | DHODHALDH1A1LMNAMAPTHPGD | |
| SCHEMBL747960 | 0.93 | CDK8 (0.32) | DHODHALDH1A1LMNAMAPTHPGD | |
| SCHEMBL748640 | 0.92 | TACR3 (0.32) | DHODHALDH1A1LMNAMAPTHPGD | |
| Hydrochloric Acid SCHEMBL748195 | 0.92 | CDK8 (0.32) | DHODHALDH1A1LMNAMAPTHPGD | |
| Hydrochloric Acid SCHEMBL749783 | 0.91 | TACR3 (0.32) | DHODHALDH1A1LMNAMAPTHPGD | |
| SCHEMBL748502 | 0.91 | DHODH (0.33) | DHODHALDH1A1LMNAMAPTHPGD | |
| Hydrochloric Acid SCHEMBL748627 | 0.90 | DHODH (0.33) | DHODHALDH1A1LMNAMAPTHPGD | |
| SCHEMBL750950 | 0.90 | SRC (0.36) | DHODHALDH1A1LMNAMAPTHPGD | |
| SCHEMBL749615 | 0.90 | MAPT (0.35) | DHODHALDH1A1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |