Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | TACR2 | P21452 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL749783 | 0.99 | TACR3 (0.32) | TACR3CDK8CLK4TACR2TACR1 | |
| SCHEMBL751895 | 0.92 | DHODH (0.33) | CDK8CLK4TACR2TACR1LMNA | |
| SCHEMBL747960 | 0.91 | CDK8 (0.32) | CDK8CLK4TACR2TACR1LMNA | |
| Hydrochloric Acid SCHEMBL750002 | 0.91 | DHODH (0.33) | CDK8CLK4TACR2TACR1LMNA | |
| SCHEMBL748805 | 0.91 | MAPT (0.36) | LMNATRPV1MAPTTP53DHODH | |
| Hydrochloric Acid SCHEMBL748195 | 0.91 | CDK8 (0.32) | CDK8CLK4TACR2TACR1LMNA | |
| SCHEMBL750950 | 0.89 | SRC (0.36) | CDK8CLK4LMNATRPV1MAPT | |
| SCHEMBL746629 | 0.88 | WDR5 (0.33) | LMNATRPV1MAPTTP53DHODH | |
| Hydrochloric Acid SCHEMBL751875 | 0.88 | SRC (0.36) | CDK8CLK4LMNATRPV1MAPT | |
| SCHEMBL749615 | 0.87 | MAPT (0.35) | LMNATRPV1MAPTTP53DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |