Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL7518990 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1HPGDCA12CA1 | |
| Phthalic Acid SCHEMBL28090264 | 0.92 | SLC7A5 (0.45) | KDM4EALDH1A1NAPRTHIF1ALMNA | |
| Histidine SCHEMBL28042776 | 0.85 | SLC7A5 (0.47) | KDM4EALDH1A1HIF1ALMNAMEN1 | |
| Histidine SCHEMBL16166274 | 0.85 | SLC7A5 (0.47) | KDM4EALDH1A1HIF1ALMNAMEN1 | |
| Histidine SCHEMBL28098393 | 0.85 | CYP1A2 (0.49) | KDM4EALDH1A1HPGDHIF1ALMNA | |
| Histidine SCHEMBL29086897 | 0.84 | SLC7A5 (0.47) | KDM4EHIF1ALMNAMEN1MAPT | |
| Histidine SCHEMBL388563 | 0.84 | SLC7A5 (0.47) | KDM4EALDH1A1HPGDHIF1ALMNA | |
| Histidine SCHEMBL163442 | 0.84 | SLC7A5 (0.47) | KDM4EALDH1A1HPGDHIF1ALMNA | |
| Histidine SCHEMBL163443 | 0.84 | SLC7A5 (0.47) | KDM4EALDH1A1HPGDHIF1ALMNA | |
| Histidine SCHEMBL3258 | 0.84 | SLC7A5 (0.47) | KDM4EALDH1A1HPGDHIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115607556-A | Medicine for preventing and treating asthma, chronic obstructive pulmonary disease, allergic diseases, etc | 刘力 | 2023-01-17 | — | — | CN | claimed |
| EP-0936899-A4 | COSMETIC COMPOSITIONS | PROCTER & GAMBLE (US) | 2002-01-02 | — | — | EP | claimed |
| US-6267978-B1 | COSMETIC FOR REGULATION OF THE OILY AND/OR SHINY APPEARANCE OF SKIN | THE PROCTER & GAMBLE COMPANY | 2001-07-31 | — | — | US | claimed |
| US-6143310-A | WATER IN OIL EMULSION CONTAINING AMINO ACID SALT OF SALICYLIC ACID | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-07 | — | — | US | claimed |
| EP-0936899-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1999-08-25 | — | — | EP | claimed |
| CN-1226820-A | Cosmetic composition | PROCTER & GAMBLE (US) | 1999-08-25 | — | — | CN | claimed |
| WO-1998010741-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-19 | — | — | WO | claimed |
| CN-115607556-A | Medicine for preventing and treating asthma, chronic obstructive pulmonary disease, allergic diseases, etc | 刘力 | 2023-01-17 | — | — | CN | disclosed |
| CN-115607516-A | Medicine for preventing and treating cold or viral diseases | 刘力 | 2023-01-17 | — | — | CN | disclosed |