Histidine

Histidine

SCHEMBL16166274

N[C@@H](Cc1c[nH]cn1)C(=O)O.Oc1ccccc1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.47
ALPI P09923 1/20 0.46
PKM P14618 1/20 0.46
PTGS1 P23219 1/20 0.46
XIAP P98170 1/20 0.46
GRIA2 P42262 1/20 0.46
CYP1A2 P05177 1/20 0.46
KMT2A Q03164 3/20 0.43
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 2/20 0.43
TSHR P16473 2/20 0.43
BLM P54132 2/20 0.43
PMP22 Q01453 2/20 0.43
MEN1 O00255 2/20 0.43
MPO P05164 1/20 0.43
HIF1A Q16665 1/20 0.43
CYP3A4 P08684 2/20 0.40
ALDH1A1 P00352 1/20 0.40
HTR1A P08908 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL28042776 1.00 SLC7A5 (0.47) SLC7A5ALPIPKMPTGS1XIAP
Histidine SCHEMBL11052850 0.95 SLC7A5 (0.43) SLC7A5ALPIPKMPTGS1XIAP
Histidine SCHEMBL28098393 0.91 CYP1A2 (0.49) SLC7A5ALPIPKMPTGS1XIAP
Tyrosine SCHEMBL25286397 0.91 SLC7A5 (0.60) SLC7A5ALPIPKMPTGS1XIAP
Histidine SCHEMBL29086897 0.90 SLC7A5 (0.47) SLC7A5ALPIPKMPTGS1XIAP
Histidine SCHEMBL995910 0.89 SLC7A5 (0.47) SLC7A5ALPIPKMPTGS1XIAP
Histidine SCHEMBL163442 0.89 SLC7A5 (0.47) SLC7A5ALPIPKMPTGS1XIAP
Histidine SCHEMBL3259 0.89 SLC7A5 (0.47) SLC7A5ALPIPKMPTGS1XIAP
Histidine SCHEMBL163443 0.89 SLC7A5 (0.47) SLC7A5ALPIPKMPTGS1XIAP
Histidine SCHEMBL8080341 0.89 SLC7A5 (0.47) SLC7A5ALPIPKMPTGS1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11045523-B2 Formulation of growth hormone albumin-binder conjugate NOVO NORDISK HEALTHCARE AG (CH) 2021-06-29 US disclosed
EP-2981282-B1 GROWTH HORMONE COMPOUND FORMULATION NOVO NORDISK HEALTHCARE AG (CH) 2020-11-04 EP disclosed
US-20160058879-A1 Growth Hormone Compound Formulation NOVO NORDISK HEALTHCARE AG (CH) 2016-03-03 US disclosed
EP-2981282-A1 GROWTH HORMONE COMPOUND FORMULATION Novo Nordisk Health Care AG (CH) 2016-02-10 EP disclosed
CN-105120887-A Growth hormone compound formulation NOVO NORDISK HEALTHCARE AG 2015-12-02 CN disclosed
WO-2014166836-A1 GROWTH HORMONE COMPOUND FORMULATION NOVO NORDISK A/S (DK) 2014-10-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11045523-B2 Formulation of growth hormone albumin-binder conjugate ALB, SHBG, SERPINA6 SLC7A5 1230/4885ALPI 716/4885PKM 4353/4885
US-20160058879-A1 Growth Hormone Compound Formulation GHRHR, GHSR, GHITM SLC7A5 1048/4885ALPI 2781/4885PKM 2085/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.