Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7555526 | 0.82 | CNR1 (0.51) | CHRNA7CNR1CNR2RORC | |
| SCHEMBL8212497 | 0.78 | LMNA (0.52) | CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL8218993 | 0.77 | LMNA (0.51) | CNR1CNR2 | |
| SCHEMBL7510780 | 0.77 | L3MBTL3 (0.37) | — | |
| SCHEMBL7511429 | 0.76 | CHRNA7 (0.46) | CHRNA7CNR1CNR2 | |
| SCHEMBL8212966 | 0.76 | TP53 (0.48) | CHRNA7CNR1CNR2RORC | |
| SCHEMBL8213939 | 0.76 | NPC1 (0.57) | CHRNA7CNR1CNR2RORC | |
| SCHEMBL7510363 | 0.76 | CNR1 (0.41) | CHRNA7CNR1CNR2RORC | |
| SCHEMBL7007153 | 0.75 | CHRNA7 (0.61) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL8213598 | 0.75 | NPC1 (0.56) | CHRNA7CNR1CNR2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |
| US-5929085-A | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |