SCHEMBL7519877

SCHEMBL7519877

ClC1c2ccccc2C(N2CCNCC2)c2ccc3c(c2C1Cl)C3

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.36
FNTA P49354 1/20 0.36
FNTB P49356 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.33
HPGD P15428 2/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
THRB P10828 1/20 0.33
ALOX12 P18054 1/20 0.33
MAPK1 P28482 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
USP2 O75604 1/20 0.33
GBA1 P04062 1/20 0.33
ALOX15 P16050 1/20 0.33
HK1 P19367 1/20 0.33
HKDC1 Q2TB90 1/20 0.33
DRD1 P21728 3/20 0.33
DRD2 P14416 2/20 0.33
DRD5 P21918 1/20 0.33
ADRA1D P25100 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7558089 0.89 TAAR1 (0.34) TAAR1FNTAFNTBSMN1; SMN2HPGD
SCHEMBL7557369 0.83 TAAR1 (0.35) TAAR1FNTAFNTBSMN1; SMN2HPGD
SCHEMBL8067630 0.83 TAAR1 (0.35) TAAR1FNTAFNTBSMN1; SMN2HPGD
SCHEMBL8068905 0.82 SMN1; SMN2 (0.30) SMN1; SMN2MAPTNPSR1
SCHEMBL8964031 0.72 TAAR1 (0.37) TAAR1FNTAFNTBUSP2GBA1
SCHEMBL8239748 0.72 TAAR1 (0.50) TAAR1FNTAFNTBSMN1; SMN2HPGD
SCHEMBL7590047 0.72
SCHEMBL25579654 0.70 TAAR1 (0.44) TAAR1FNTAFNTBSMN1; SMN2HPGD
SCHEMBL8067779 0.69 TAAR1 (0.42) TAAR1FNTAFNTBSMN1; SMN2HPGD
SCHEMBL6161969 0.69 TAAR1 (0.58) TAAR1FNTAFNTBDRD1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002005818-A2 NOVEL METHOD OF USE OF MULTIDRUG RESISTANCE MODULATORS ELI LILLY AND COMPANY (US) 2002-01-24 WO disclosed
US-6087365-A TREATING DRUG-RESISTANT MALARIA IN A MAMMAL ELI LILLY AND COMPANY 2000-07-11 US disclosed
US-5889007-A CHEMISENSITIZING AGENTS; CANCER THERAPY DRUG RESISTANCE SYNTEX (U.S.A.) INC. (US) 1999-03-30 US disclosed
US-5874434-A SENSITIZERS FOR CANCER DRUGS SYNTEX (U.S.A.) INC. (US) 1999-02-23 US disclosed
EP-0695293-B1 10,11-METHANODIBENZOSUBERANE DERIVATIVES USED AS CHEMOSENSITIZING AGENTS SYNTEX INC (US) 1998-10-14 EP disclosed
EP-0866063-A1 10, 11-Methanodibenzosuberane derivatives used as chemosensitizing agents SYNTEX (U.S.A.) INC. (US) 1998-09-23 EP disclosed
US-5654304-A CHEMOSENSITIZING AGENTS; CANCER THERAPY; DRUG RESISTANCE SYNTEX (U.S.A.) INC. (US) 1997-08-05 US disclosed
US-5643909-A CHEMICAL SENSITIZERS FOR CANCER CHEMOTHERAPY FOR MULTIDRUG RESISTANCE SYNTEX (U.S.A.) INC. (US) 1997-07-01 US disclosed
EP-0695293-A1 10,11-METHANODIBENZOSUBERANE DERIVATIVES USED AS CHEMOSENSITIZING AGENTS SYNTEX (U.S.A.) INC. (US) 1996-02-07 EP disclosed
WO-1994024107-A1 10,11-METHANODIBENZOSUBERANE DERIVATIVES USED AS CHEMOSENSITIZING AGENTS SYNTEX (U.S.A.) INC. (US) 1994-10-27 WO disclosed