Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7590047 | 0.89 | — | — | |
| SCHEMBL8058657 | 0.84 | — | — | |
| SCHEMBL7521956 | 0.84 | GAA (0.30) | — | |
| SCHEMBL7519877 | 0.82 | TAAR1 (0.36) | SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL7558089 | 0.72 | TAAR1 (0.34) | SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL8331102 | 0.70 | ALDH1A1 (0.36) | SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL1798052 | 0.70 | ALDH1A1 (0.51) | SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL8058524 | 0.68 | ABCB1 (0.70) | MAPTNPSR1 | |
| SCHEMBL7557369 | 0.66 | TAAR1 (0.35) | SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL8067630 | 0.66 | TAAR1 (0.35) | SMN1; SMN2MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6087365-A | TREATING DRUG-RESISTANT MALARIA IN A MAMMAL | ELI LILLY AND COMPANY | 2000-07-11 | — | — | US | disclosed |
| US-5889007-A | CHEMISENSITIZING AGENTS; CANCER THERAPY DRUG RESISTANCE | SYNTEX (U.S.A.) INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5874434-A | SENSITIZERS FOR CANCER DRUGS | SYNTEX (U.S.A.) INC. (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0695293-B1 | 10,11-METHANODIBENZOSUBERANE DERIVATIVES USED AS CHEMOSENSITIZING AGENTS | SYNTEX INC (US) | 1998-10-14 | — | — | EP | disclosed |
| EP-0866063-A1 | 10, 11-Methanodibenzosuberane derivatives used as chemosensitizing agents | SYNTEX (U.S.A.) INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5654304-A | CHEMOSENSITIZING AGENTS; CANCER THERAPY; DRUG RESISTANCE | SYNTEX (U.S.A.) INC. (US) | 1997-08-05 | — | — | US | disclosed |
| US-5643909-A | CHEMICAL SENSITIZERS FOR CANCER CHEMOTHERAPY FOR MULTIDRUG RESISTANCE | SYNTEX (U.S.A.) INC. (US) | 1997-07-01 | — | — | US | disclosed |