⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058657 | 0.91 | — | — | |
| SCHEMBL8068905 | 0.89 | SMN1; SMN2 (0.30) | — | |
| SCHEMBL7558089 | 0.83 | TAAR1 (0.34) | — | |
| SCHEMBL7521956 | 0.81 | GAA (0.30) | — | |
| SCHEMBL8067630 | 0.73 | TAAR1 (0.35) | — | |
| SCHEMBL7519877 | 0.72 | TAAR1 (0.36) | — | |
| SCHEMBL8331102 | 0.68 | ALDH1A1 (0.36) | — | |
| SCHEMBL1798052 | 0.68 | ALDH1A1 (0.51) | — | |
| SCHEMBL8074346 | 0.66 | MAOA (0.35) | — | |
| SCHEMBL8069075 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002005818-A2 | NOVEL METHOD OF USE OF MULTIDRUG RESISTANCE MODULATORS | ELI LILLY AND COMPANY (US) | 2002-01-24 | — | — | WO | disclosed |
| US-6087365-A | TREATING DRUG-RESISTANT MALARIA IN A MAMMAL | ELI LILLY AND COMPANY | 2000-07-11 | — | — | US | disclosed |
| US-5889007-A | CHEMISENSITIZING AGENTS; CANCER THERAPY DRUG RESISTANCE | SYNTEX (U.S.A.) INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5874434-A | SENSITIZERS FOR CANCER DRUGS | SYNTEX (U.S.A.) INC. (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0695293-B1 | 10,11-METHANODIBENZOSUBERANE DERIVATIVES USED AS CHEMOSENSITIZING AGENTS | SYNTEX INC (US) | 1998-10-14 | — | — | EP | disclosed |
| EP-0866063-A1 | 10, 11-Methanodibenzosuberane derivatives used as chemosensitizing agents | SYNTEX (U.S.A.) INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5654304-A | CHEMOSENSITIZING AGENTS; CANCER THERAPY; DRUG RESISTANCE | SYNTEX (U.S.A.) INC. (US) | 1997-08-05 | — | — | US | disclosed |
| US-5643909-A | CHEMICAL SENSITIZERS FOR CANCER CHEMOTHERAPY FOR MULTIDRUG RESISTANCE | SYNTEX (U.S.A.) INC. (US) | 1997-07-01 | — | — | US | disclosed |