Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7514619 | 0.85 | AR (0.42) | ARKMT2AMEN1MAPTHDAC1 | |
| SCHEMBL7516038 | 0.85 | LMNA (0.43) | ARLMNATRPC5SMN1; SMN2KMT2A | |
| SCHEMBL7513782 | 0.81 | AR (0.45) | ARTRPC5KMT2AMEN1COMT | |
| SCHEMBL7510407 | 0.81 | ADORA3 (0.51) | ARHSD17B10 | |
| SCHEMBL7477607 | 0.80 | PARP1 (0.43) | ARKDM4ALMNAHSD17B10CHRNE | |
| SCHEMBL7511491 | 0.75 | LMNA (0.39) | LMNAPTGS2SMN1; SMN2HDAC1 | |
| SCHEMBL7509410 | 0.72 | TYR (0.44) | KMT2AMEN1IDO1TDO2MAPT | |
| SCHEMBL7509548 | 0.71 | KMT2A (0.44) | LMNASMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL29050065 | 0.64 | CHRNE (0.43) | LMNACHRNEPTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL7482606 | 0.64 | MEN1 (0.56) | LMNASMN1; SMN2KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181292-A1 | PYROZOLO [3,4-D][1,2,3] TRIAZINES WITH AN ANTICONVULSIVE ACTION AND METHODS FOR PRODUCING THE SAME | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000073309-A1 | PYROZOLO [3,4-D][1,2,3] TRIAZINES WITH AN ANTICONVULSIVE ACTION AND METHODS FOR PRODUCING THE SAME | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-12-07 | — | — | WO | claimed |
| US-6316448-B1 | Pyrazolo[3,4-d][1,2,3] troazines having anticonvulsant activity and process for their preparation | ZENTARIS GMBH (DE) | 2001-11-13 | — | — | US | disclosed |