Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA5A | P35218 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.39 |
| ▸ | VHL | P40337 | 1/20 | 0.39 |
| ▸ | ELOC | Q15369 | 1/20 | 0.39 |
| ▸ | ELOB | Q15370 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745550 | 0.85 | GFER (0.42) | CA2LTA4HESR1ESR2TDP1 | |
| SCHEMBL3360491 | 0.83 | CA2 (0.59) | TSHRCA2CA12CA1CA4 | |
| SCHEMBL7539245 | 0.82 | CHKA (0.58) | TSHRCHKAPRSS1PRSS2PRSS3 | |
| SCHEMBL41775 | 0.78 | TSHR (0.67) | TSHRCHKAPRSS1PRSS2PRSS3 | |
| SCHEMBL503866 | 0.78 | ESR1 (0.68) | CA2LTA4HESR1ESR2TDP1 | |
| SCHEMBL25301605 | 0.77 | TSHR (0.50) | TSHRCHKAPRSS1PRSS2PRSS3 | |
| SCHEMBL40703 | 0.77 | CA2 (0.65) | TSHRCHKAPRSS1PRSS2PRSS3 | |
| SCHEMBL2686386 | 0.77 | TSHR (0.50) | TSHRCHKAPRSS1PRSS2PRSS3 | |
| Formaldehyde SCHEMBL8673672 | 0.76 | TSHR (0.56) | TSHRCHKAPRSS1PRSS2PRSS3 | |
| SCHEMBL7771585 | 0.75 | ENPP2 (0.47) | TSHRPRSS1PRSS2PRSS3DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584223-B1 | NOVEL IMMUNOSUPPRESSIVE COMPOUNDS | VERTEX PHARMA (US) | 1999-08-11 | — | — | EP | claimed |
| US-5620971-A | Biologically active acylated amino acid derivatives | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1997-04-15 | — | — | US | claimed |
| EP-0584223-A1 | NOVEL IMMUNOSUPPRESSIVE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1994-03-02 | — | — | EP | claimed |
| WO-1992019593-A1 | NOVEL IMMUNOSUPPRESSIVE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1992-11-12 | — | — | WO | claimed |
| CN-1494906-A | Application of compound in preparation of medicine for preventing and curing multiple drug resistance | ��̩��˹ҩ��ɷ�����˾ | 2004-05-12 | — | — | CN | disclosed |
| CN-1367678-A | Method of treating hair loss using ketoamides | PROCTER & GAMBLE (US) | 2002-09-04 | — | — | CN | disclosed |
| CN-1086386-C | Multi-drug resistance modifiers | VERTEX PHARMA (US) | 2002-06-19 | — | — | CN | disclosed |
| EP-1179529-A1 | NOVEL HYDROXAMIC ACID DERIVATIVES | Daiichi Fine Chemical Co., Ltd. (JP) | 2002-02-13 | — | — | EP | disclosed |
| CN-1320028-A | Method of treating hair loss using sulfonamides | PROCTER & GAMBLE (US) | 2001-10-31 | — | — | CN | disclosed |
| EP-1117371-A2 | METHOD OF TREATING HAIR LOSS USING KETOAMIDES | The Procter & Gamble Company (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-1117372-A2 | METHOD OF TREATING HAIR LOSS USING SULFONAMIDES | THE PROCTER & GAMBLE COMPANY (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-1101492-A1 | NOVEL REMEDIES FOR ALLERGIC DISEASES | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 2001-05-23 | — | — | EP | disclosed |
| EP-1038864-A1 | NOVEL METALLOPROTEINASE INHIBITORS | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 2000-09-27 | — | — | EP | disclosed |
| WO-2000018358-A2 | METHOD OF TREATING HAIR LOSS USING KETOAMIDES | THE PROCTER & GAMBLE COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |
| WO-2000018361-A2 | METHOD OF TREATING HAIR LOSS USING SULFONAMIDES | THE PROCTER & GAMBLE COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |
| CN-1202104-A | Methods and compositions for stimulating neurite growth | VERTEX PHARMA (US) | 1998-12-16 | — | — | CN | disclosed |
| CN-1088577-A | Novel multi-drug resistance modifiers | VERTEX PHARMA (US) | 1994-06-29 | — | — | CN | disclosed |