Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BHMT | Q93088 | 3/20 | 0.37 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.36 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7520214 | 1.00 | SLC7A5 (0.64) | SLC7A5ALDH1A1SLC1A3SLC1A2SLC1A1 | |
| Citric Acid SCHEMBL30573733 | 0.95 | SLC7A5 (0.58) | SLC7A5ALDH1A1SLC1A3SLC1A2SLC1A1 | |
| Leucine SCHEMBL20898409 | 0.84 | SLC7A5 (0.67) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Citric Acid SCHEMBL1565952 | 0.83 | ALDH1A1 (0.60) | SLC7A5ALDH1A1SLC1A3SLC1A2SLC1A1 | |
| Citric Acid SCHEMBL1565943 | 0.83 | ALDH1A1 (0.60) | SLC7A5ALDH1A1SLC1A3SLC1A2SLC1A1 | |
| Leucine SCHEMBL935695 | 0.83 | SLC7A5 (0.60) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Leucine SCHEMBL935696 | 0.83 | SLC7A5 (0.60) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Citric Acid SCHEMBL21043934 | 0.83 | ALDH1A1 (0.65) | SLC7A5ALDH1A1KDM4ELMNAMAPT | |
| Citric Acid SCHEMBL21145087 | 0.82 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL6654790 | 0.82 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116573999-A | Alpha-hydroxy organic acid-amino acid and analogue divalent metal co-salt compound thereof, and preparation method and application thereof | 天宝动物营养科技股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| WO-2015168669-A1 | HUMAN HEALTH PROPERTY MONITORING SYSTEM | HALL DAVID R (US) | 2015-11-05 | — | — | WO | disclosed |
| EP-1169053-A1 | PULMONARY ADMINISTRATION OF DRY POWDER FORMULATIONS FOR TREATING INFERTILITY | Inhale Therapeutic Systems, Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061178-A1 | PULMONARY ADMINISTRATION OF DRY POWDER FORMULATIONS FOR TREATING INFERTILITY | INHALE THERAPEUTICS SYSTEMS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |