Leucine

Leucine

SCHEMBL935696

CC(C)C(O)(CC(=O)O)C(=O)O.CC(C)C[C@H](N)C(=O)O

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.60
SLC1A3 P43003 5/20 0.49
SLC1A2 P43004 5/20 0.49
SLC1A1 P43005 4/20 0.46
CPT2 P23786 1/20 0.46
ACLY P53396 1/20 0.46
HSPD1 P10809 1/20 0.40
BLM P54132 1/20 0.40
HSPE1 P61604 1/20 0.40
GRIK1 P39086 6/20 0.37
GRIK2 Q13002 5/20 0.37
BHMT Q93088 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL935695 1.00 SLC7A5 (0.60) SLC7A5SLC1A3SLC1A2SLC1A1CPT2
Citric Acid SCHEMBL7520219 0.83 SLC7A5 (0.64) SLC7A5SLC1A3SLC1A2SLC1A1CPT2
Citric Acid SCHEMBL7520214 0.83 SLC7A5 (0.64) SLC7A5SLC1A3SLC1A2SLC1A1CPT2
SCHEMBL59972 0.82 ACLY (0.58) CPT2ACLYHSPD1BLMHSPE1
SCHEMBL1462468 0.82 ACLY (0.58) CPT2ACLYHSPD1BLMHSPE1
SCHEMBL1409965 0.82 ACLY (0.58) CPT2ACLYHSPD1BLMHSPE1
Leucine SCHEMBL20898409 0.81 SLC7A5 (0.67) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Citric Acid SCHEMBL30573733 0.79 SLC7A5 (0.58) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL15602684 0.78 SLC7A5 (0.90) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL25241602 0.78 SLC7A5 (1.00) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2456894-A1 SORGHUM CENTROMERE SEQUENCES AND MINICHROMOSOMES Chromatin, Inc. (US) 2012-05-30 EP disclosed
WO-2011011693-A1 SORGHUM CENTROMERE SEQUENCES AND MINICHROMOSOMES CHROMATIN, INC. (US) 2011-01-27 WO disclosed