Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524049 | 0.79 | PNMT (0.38) | KDM4EMAPTHPGDKMT2AHSD17B10 | |
| SCHEMBL7531086 | 0.78 | KMT2A (0.57) | KDM4EMAPTHPGDKMT2AHSD17B10 | |
| SCHEMBL7529359 | 0.74 | KMT2A (0.50) | KDM4EMAPTHPGDKMT2AHSD17B10 | |
| SCHEMBL9017220 | 0.67 | PNMT (0.45) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL7464396 | 0.67 | PNMT (0.49) | KDM4EMAPTHPGDKMT2AHSD17B10 | |
| SCHEMBL11338117 | 0.67 | PNMT (0.46) | ALDH1A1CYP2C19PNMTCYP1A2CYP2D6 | |
| SCHEMBL7524111 | 0.66 | PNMT (0.38) | KDM4EMAPTHPGDKMT2AHSD17B10 | |
| SCHEMBL29549101 | 0.66 | KMT2A (0.52) | KDM4EMAPTHPGDKMT2AHSD17B10 | |
| SCHEMBL22531716 | 0.66 | KMT2A (0.52) | KDM4EMAPTHPGDKMT2AHSD17B10 | |
| SCHEMBL30897551 | 0.65 | GPR35 (0.41) | KDM4EMAPTHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003747-A4 | CARBAPENEMS WITH NAPHTHOSULTAM DERIVATIVE LINKED VIA METHYLENE | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6251890-B1 | TREATING OR PREVENTING BACTERIAL INFECTIONS IN MAMMALIAN PATIENTS | MERCK & CO., INC. | 2001-06-26 | — | — | US | disclosed |
| EP-1003747-A1 | CARBAPENEMS WITH NAPHTHOSULTAM DERIVATIVE LINKED VIA METHYLENE | Merck & Co., Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009032-A1 | CARBAPENEMS WITH NAPHTHOSULTAM DERIVATIVE LINKED VIA METHYLENE | MERCK & CO., INC. (US) | 1999-02-25 | — | — | WO | disclosed |