SCHEMBL7520600

SCHEMBL7520600

COC(=O)CCON1C(C)(C)CC(OCc2ccc(COC3CC(C)(C)N(OCCC(=O)OC)C(C)(C)C3)cc2)CC1(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.39
MEN1 O00255 1/20 0.39
GAA P10253 1/20 0.39
TSHR P16473 2/20 0.36
EPHX2 P34913 4/20 0.36
HRH3 Q9Y5N1 1/20 0.36
ALDH1A1 P00352 3/20 0.35
HSD17B10 Q99714 2/20 0.35
ESR1 P03372 1/20 0.35
CNR1 P21554 1/20 0.34
CNR2 P34972 1/20 0.34
CARM1 Q86X55 3/20 0.33
PRMT6 Q96LA8 3/20 0.33
LTA4H P09960 1/20 0.33
HDAC4 P56524 1/20 0.33
LMNA P02545 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
EZH2 Q15910 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7523780 0.94 TSHR (0.42) KMT2AMEN1GAATSHREPHX2
SCHEMBL9243820 0.82 TSHR (0.48) KMT2AMEN1GAATSHRALDH1A1
SCHEMBL7476490 0.78 CARM1 (0.36) KMT2ATSHRHRH3ALDH1A1HSD17B10
SCHEMBL13008625 0.78 TSHR (0.38) KMT2AMEN1GAATSHREPHX2
SCHEMBL9241957 0.78 KMT2A (0.38) KMT2AMEN1GAATSHREPHX2
SCHEMBL9371206 0.77 TSHR (0.62) KMT2AMEN1GAATSHRALDH1A1
SCHEMBL9374559 0.76 TSHR (0.52) KMT2AMEN1GAATSHRALDH1A1
SCHEMBL7475314 0.75 CARM1 (0.45) KMT2ATSHRHRH3ALDH1A1CARM1
SCHEMBL9335197 0.75 CARM1 (0.42) KMT2ATSHREPHX2HRH3ALDH1A1
SCHEMBL9440082 0.74 CARM1 (0.46) KMT2ATSHREPHX2HRH3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0389422-B1 Stabilizers derived from N-hydroxy hindered amines by Michael addition reactions CIBA GEIGY AG (CH) 1994-09-21 EP claimed
US-5015678-A Light stabilized polymers by the addition of N-hydoxyamines CIBA-GEIGY CORPORATION (US) 1991-05-14 US claimed
EP-0389422-A2 Stabilizers derived from N-hydroxy hindered amines by Michael addition reactions CIBA-GEIGY AG (CH) 1990-09-26 EP claimed
US-6500303-B1 DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL; PROTECTION FROM ULTRAVIOLET, FLUORESCENT AND SUN LIGHT EXPOSURE CIBA SPECIALTY CHEMICALS CORPORATION 2002-12-31 US disclosed
US-20020124980-A1 Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives SELTZER RAYMOND R (US) 2002-09-12 US disclosed
US-6447644-B1 PULP OR PAPER THAT STILL CONTAINS LIGNIN, AND A STERICALLY HINDERED AMINE, FOR EXAMPLE DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL CIBA SPECIALTY CHEMICALS CORPORATION 2002-09-10 US disclosed
US-6254724-B1 STABILIZING AMOUNT OF A HINDERED AMINE COMPOUND SELECTED DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL OR WHICH ARE THEIR HYDROXYLAMINE SALTS CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-03 US disclosed
EP-1000032-A1 INHIBITION OF PULP AND PAPER YELLOWING USING NITROXIDES AND OTHER COADDITIVES Ciba SC Holding AG (CH) 2000-05-17 EP disclosed
WO-1999005108-A1 INHIBITION OF PULP AND PAPER YELLOWING USING NITROXIDES AND OTHER COADDITIVES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1999-02-04 WO disclosed
EP-0389422-B1 Stabilizers derived from N-hydroxy hindered amines by Michael addition reactions CIBA GEIGY AG (CH) 1994-09-21 EP disclosed
US-5015678-A Light stabilized polymers by the addition of N-hydoxyamines CIBA-GEIGY CORPORATION (US) 1991-05-14 US disclosed
EP-0389422-A2 Stabilizers derived from N-hydroxy hindered amines by Michael addition reactions CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed