Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM4B | O94953 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513779 | 1.00 | AHR (0.35) | AHRPDE3BPDE3AGPR183APP | |
| SCHEMBL7513769 | 1.00 | AHR (0.35) | AHRPDE3BPDE3AGPR183APP | |
| SCHEMBL7515514 | 0.77 | AHR (0.47) | AHRHDAC1HDAC8HDAC6 | |
| SCHEMBL7515524 | 0.77 | AHR (0.47) | AHRHDAC1HDAC8HDAC6 | |
| SCHEMBL7519323 | 0.77 | AHR (0.47) | AHRHDAC1HDAC8HDAC6 | |
| SCHEMBL7520340 | 0.76 | MAOB (0.46) | AHRDAOMAOB | |
| SCHEMBL7520343 | 0.76 | MAOB (0.46) | AHRDAOMAOB | |
| SCHEMBL7524917 | 0.70 | ULK1 (0.39) | PDE3BPDE3AKDR | |
| SCHEMBL7518829 | 0.70 | PTGS1 (0.39) | APPMAOB | |
| SCHEMBL7518821 | 0.70 | PTGS1 (0.39) | APPMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |