Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29230461 | 0.82 | ALDH1A1 (0.53) | POLBHDAC1MAPK1HPGDNPC1 | |
| SCHEMBL1110180 | 0.79 | MDM4 (0.73) | MDM4TP53POLBHDAC3HDAC1 | |
| SCHEMBL13846447 | 0.79 | MAPT (0.54) | TP53POLBMAPK1HPGDNPC1 | |
| SCHEMBL13846438 | 0.79 | NFE2L2 (0.41) | TP53POLBHDAC3HDAC1HDAC2 | |
| SCHEMBL13846445 | 0.76 | MAPT (0.59) | TP53POLBMAPK1HPGDNPC1 | |
| SCHEMBL10953014 | 0.74 | HDAC3 (0.71) | MDM4TP53POLBHDAC3HDAC1 | |
| SCHEMBL6067716 | 0.74 | HDAC1 (0.66) | MDM4TP53POLBHDAC3HDAC1 | |
| SCHEMBL19509669 | 0.74 | HDAC3 (0.66) | MDM4TP53POLBHDAC3HDAC1 | |
| SCHEMBL2044796 | 0.73 | TDP1 (0.50) | TP53MAPK1HPGDCYP1A2CYP3A4 | |
| SCHEMBL3148472 | 0.72 | NPC1 (0.82) | MDM4TP53POLBHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117700456-A | Arylamine photocatalyst and preparation method thereof, defluorinated mono-bridged ring propeller compound, preparation method and application thereof | 国科大杭州高等研究院 | 2024-03-15 | — | — | CN | claimed |
| CN-117700456-A | Arylamine photocatalyst and preparation method thereof, defluorinated mono-bridged ring propeller compound, preparation method and application thereof | 国科大杭州高等研究院 | 2024-03-15 | — | — | CN | disclosed |
| EP-0973784-B1 | PREPARATION OF TERTIARY PHOSPHINES VIA NICKEL-CATALYZED CROSS COUPLING | PCBU SERVICES INC (US) | 2002-01-16 | — | — | EP | disclosed |
| US-5902904-A | Method for preparation of tertiary phosphines via nickel-catalyzed cross coupling | MONSANTO COMPANY (US) | 1999-05-11 | — | — | US | disclosed |
| US-5874628-A | Method for preparation of tertiary phosphines via nickel-catalyzed cross coupling | MONSANTO COMPANY (US) | 1999-02-23 | — | — | US | disclosed |