Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878871 | 0.83 | MMP3 (0.36) | MMP3MMP12HDAC1AGTR1PPARG | |
| SCHEMBL7518256 | 0.79 | NPC1 (0.36) | NPC1NFKB1MAPK1RAB9ANFKB2 | |
| SCHEMBL7510620 | 0.78 | AGTR1 (0.61) | AGTR1PPARGAGTR2 | |
| SCHEMBL7508623 | 0.77 | RARB (0.40) | AGTR1AGTR2 | |
| SCHEMBL7510644 | 0.76 | AGTR1 (0.43) | AGTR1PPARGAGTR2 | |
| SCHEMBL7507671 | 0.76 | EGFR (0.45) | HDAC1AGTR1PPARGNPC1RAB9A | |
| SCHEMBL8878903 | 0.74 | AR (0.38) | SMN1; SMN2 | |
| SCHEMBL20341902 | 0.73 | TLR7 (0.41) | EGFR | |
| Ammonia Solution, Strong SCHEMBL6629978 | 0.72 | HDAC1 (0.41) | HDAC1AGTR1PPARGKCNH2SMN1; SMN2 | |
| SCHEMBL7510474 | 0.72 | EGFR (0.40) | HDAC1AGTR1KCNH2L3MBTL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556080-B1 | Bicyclic pyridine derivatives, process for their preparation, intermediates, their use as medicaments and pharmaceutical compositions containing them | AVENTIS PHARMA SA (FR) | 2002-05-08 | — | — | EP | disclosed |
| US-5691347-A | ANGIOTENSIN II INHIBITORS AND VASOCONSTRICTION | ROUSSEL UCLAF (FR) | 1997-11-25 | — | — | US | disclosed |
| US-5650414-A | PYRAZOLOPYRIDINES OR IMIDAZOLOPYRIDINES | ROUSSEL UCLAF (FR) | 1997-07-22 | — | — | US | disclosed |
| EP-0556080-A1 | Bicyclic pyridine derivatives, process for their preparation, intermediates, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1993-08-18 | — | — | EP | disclosed |