Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 6/20 | 0.66 |
| ▸ | ESR1 | P03372 | 5/20 | 0.66 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.66 |
| ▸ | PGR | P06401 | 2/20 | 0.66 |
| ▸ | AR | P10275 | 2/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.66 |
| ▸ | SHBG | P04278 | 1/20 | 0.66 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10349423 | 0.90 | MAPT (0.74) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL21523188 | 0.89 | ESR1 (0.67) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL1999916 | 0.89 | LMNA (0.71) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL1999913 | 0.89 | LMNA (0.71) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL7518726 | 0.89 | LMNA (0.71) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL5527384 | 0.87 | KMT2A (0.71) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL8623738 | 0.84 | ESR1 (0.75) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL8623741 | 0.84 | ESR1 (0.75) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL17814221 | 0.84 | ESR1 (0.75) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| Estradiol Propionate SCHEMBL480992 | 0.84 | MAPT (1.00) | KMT2AMAPTMEN1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476012-B2 | FOR THERAPY OF SYMPTOMOLOGY ASSOCIATED WITH MENOPAUSE | YALE UNIVERSITY | 2002-11-05 | — | — | US | disclosed |
| US-20020143002-A1 | Estradiol-16alpha-carboxylic acid esters as locally active estrogens | YALE UNIVERSITY | 2002-10-03 | — | — | US | disclosed |
| WO-2002058634-A2 | ESTRADIOL-16α-CARBOXYLIC ACID ESTERS AS LOCALLY ACTIVE ESTROGENS | YALE UNIVERSITY (US) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020143002-A1 | Estradiol-16alpha-carboxylic acid esters as locally active estrogens | ESR1, ESR2, GPER1 | KMT2A 307/4885MAPT 4839/4885MEN1 1823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.