Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 8/20 | 0.51 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | USP14 | P54578 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7522232 | 0.94 | SUV39H2 (0.53) | SUV39H2CKS1BSKP1SKP2DRD2 | |
| SCHEMBL27655935 | 0.89 | SUV39H2 (0.54) | SUV39H2CKS1BSKP1SKP2DRD2 | |
| SCHEMBL21397261 | 0.85 | SUV39H2 (0.51) | SUV39H2CKS1BSKP1SKP2DRD2 | |
| SCHEMBL3108407 | 0.82 | CNR1 (0.55) | SUV39H2CKS1BSKP1SKP2DRD2 | |
| SCHEMBL25453973 | 0.81 | SUV39H2 (0.50) | SUV39H2CKS1BSKP1SKP2DRD2 | |
| SCHEMBL383106 | 0.81 | USP2 (0.56) | SUV39H2CKS1BSKP1SKP2DRD2 | |
| SCHEMBL28489283 | 0.81 | AR (0.52) | SUV39H2DRD2CNR1CNR2DRD3 | |
| SCHEMBL25703973 | 0.80 | SUV39H2 (0.54) | SUV39H2 | |
| SCHEMBL25285177 | 0.80 | SUV39H2 (0.54) | SUV39H2 | |
| SCHEMBL2271966 | 0.80 | SUV39H2 (0.52) | SUV39H2CKS1BSKP1SKP2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492355-B1 | Adamantane derivatives | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1171432-A1 | ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061569-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |