SCHEMBL7522167

SCHEMBL7522167

O=C1CNC2CC=CCC2NCC(=O)NC2CCCCC2N1

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.37
PKM P14618 1/20 0.37
LMNA P02545 1/20 0.33
TSHR P16473 1/20 0.33
PARP1 P09874 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL796903 0.87 ALDH1A1 (0.42) ALDH1A1PKMLMNATSHRPARP1
SCHEMBL20959501 0.87 ALDH1A1 (0.42) ALDH1A1PKMLMNATSHRPARP1
SCHEMBL20980365 0.87 ALDH1A1 (0.42) ALDH1A1PKMLMNATSHRPARP1
SCHEMBL1005944 0.87 ALDH1A1 (0.42) ALDH1A1PKMLMNATSHRPARP1
SCHEMBL15817820 0.83 ALDH1A1 (0.37) ALDH1A1PKM
SCHEMBL15819417 0.83 ALDH1A1 (0.37) ALDH1A1PKM
O-Xylene SCHEMBL11227111 0.78 TSHR (0.39) LMNATSHRPARP1
SCHEMBL6156594 0.75 GAA (0.31)
SCHEMBL6155008 0.68 OR51E2 (0.37) ALDH1A1PKM
SCHEMBL2904793 0.67 ALDH1A1 (0.55) ALDH1A1PKMLMNATSHRPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1184377-A1 Hepatobiliary magnetic resonance contrast agents BRACCO International B.V. (NL) 2002-03-06 EP disclosed
WO-1995009161-A1 HEPATOBILIARY MAGNETIC RESONANCE CONTRAST AGENTS BRACCO INTERNATIONAL B.V. (NL) 1995-04-06 WO disclosed
US-5358704-A Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents BRISTOL-MYERS SQUIBB (US) 1994-10-25 US disclosed