Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1189771 | 1.00 | ALDH1A1 (0.55) | ALDH1A1PKMPARP1LMNATSHR | |
| SCHEMBL27848116 | 1.00 | ALDH1A1 (0.55) | ALDH1A1PKMPARP1LMNATSHR | |
| SCHEMBL19546338 | 0.97 | ALDH1A1 (0.52) | ALDH1A1PKMPARP1LMNATSHR | |
| SCHEMBL19546339 | 0.97 | ALDH1A1 (0.52) | ALDH1A1PKMPARP1LMNATSHR | |
| SCHEMBL12601191 | 0.84 | ALDH1A1 (0.52) | ALDH1A1PKMPARP1LMNATSHR | |
| SCHEMBL22579511 | 0.84 | ALDH1A1 (0.52) | ALDH1A1PKMPARP1LMNATSHR | |
| SCHEMBL31093217 | 0.84 | ALDH1A1 (0.52) | ALDH1A1PKMPARP1LMNATSHR | |
| SCHEMBL2881411 | 0.84 | ALDH1A1 (0.52) | ALDH1A1PKMPARP1LMNATSHR | |
| SCHEMBL13587011 | 0.79 | LMNA (0.53) | ALDH1A1PKMPARP1LMNATSHR | |
| SCHEMBL6737826 | 0.78 | PARP1 (0.46) | ALDH1A1PKMPARP1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234987-B1 | PERHYDROQUINOXALINE DERIVATIVES AS ANALGESICS | WOLFF AUGUST GMBH & CO KG ARZNEIMITTEL DR (DE) | 2012-12-12 | — | — | EP | claimed |
| US-8309725-B2 | Perhydroquinoxaline derivatives, their preparation and use in medicaments | Dr. August Wolff GmbH & Co. KG—Arzneimittel (DE) | 2012-11-13 | — | — | US | claimed |
| US-20100311761-A1 | PERHYDROQUINOXALINE DERIVATIVES | DR. AUGUST WOLFF GMBH & CO. KG - ARZNEIMITTEL (DE) | 2010-12-09 | — | — | US | claimed |
| US-8309725-B2 | Perhydroquinoxaline derivatives, their preparation and use in medicaments | Dr. August Wolff GmbH & Co. KG—Arzneimittel (DE) | 2012-11-13 | — | — | US | disclosed |
| US-20100311761-A1 | PERHYDROQUINOXALINE DERIVATIVES | DR. AUGUST WOLFF GMBH & CO. KG - ARZNEIMITTEL (DE) | 2010-12-09 | — | — | US | disclosed |
| EP-2217226-A1 | PEPTIDE DEFORMYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061879-A1 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311761-A1 | PERHYDROQUINOXALINE DERIVATIVES | FH, HOGA1, SDHA | ALDH1A1 973/4885PKM 228/4885PARP1 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.