Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515130 | 0.91 | ITGAL (0.47) | CNR2NCF1PTPN11DHFR | |
| SCHEMBL7516894 | 0.84 | RXFP1 (0.55) | CNR2SMONCF1PTPN11CKS1B | |
| SCHEMBL7514586 | 0.84 | ITGAL (0.52) | CNR2SMONCF1PTPN11DHFR | |
| SCHEMBL7519963 | 0.83 | CKS1B (0.46) | CNR2SMONCF1PTPN11CKS1B | |
| SCHEMBL7512812 | 0.82 | PTPN11 (0.43) | CNR2SMONCF1ALKPTPN11 | |
| SCHEMBL7520946 | 0.81 | ITGAL (0.41) | CNR2SMONCF1CKS1BSKP1 | |
| SCHEMBL7514841 | 0.81 | CLK1 (0.42) | SMONCF1DHFR | |
| SCHEMBL7508846 | 0.81 | RXFP1 (0.44) | SMONCF1PTPN11CKS1BSKP1 | |
| SCHEMBL7519326 | 0.80 | ALDH1A1 (0.43) | CNR2NCF1DHFRMEN1KMT2A | |
| SCHEMBL7516678 | 0.80 | RXFP1 (0.41) | SMONCF1PTPN11CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |