Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ITGAL | P20701 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508846 | 0.90 | RXFP1 (0.44) | RXFP1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7519963 | 0.90 | CKS1B (0.46) | RXFP1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7516678 | 0.89 | RXFP1 (0.41) | RXFP1ALDH1A1NCF1AKT1DHFR | |
| SCHEMBL7519270 | 0.88 | ALDH1A1 (0.42) | RXFP1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7514338 | 0.88 | RXFP1 (0.45) | RXFP1ALDH1A1LMNAITGALKDM4E | |
| SCHEMBL7514586 | 0.86 | ITGAL (0.52) | LMNAITGALSMN1; SMN2NCF1HPGD | |
| SCHEMBL7518286 | 0.86 | EIF2AK4 (0.46) | RXFP1ALDH1A1LMNAITGALSMN1; SMN2 | |
| SCHEMBL7514841 | 0.85 | CLK1 (0.42) | RXFP1LMNAITGALKDM4EPI4KB | |
| SCHEMBL7522989 | 0.84 | CNR2 (0.44) | NCF1CNR2DHFRSMOPTPN11 | |
| SCHEMBL7519326 | 0.84 | ALDH1A1 (0.43) | RXFP1ALDH1A1ITGALKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |