Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508846 | 0.90 | RXFP1 (0.44) | RXFP1ALDH1A1PTPN11CKS1BSKP1 | |
| SCHEMBL7519963 | 0.90 | CKS1B (0.46) | RXFP1ALDH1A1PTPN11CKS1BSKP1 | |
| SCHEMBL7516894 | 0.89 | RXFP1 (0.55) | RXFP1ALDH1A1NPC1PTPN11CKS1B | |
| SCHEMBL7519270 | 0.88 | ALDH1A1 (0.42) | RXFP1ALDH1A1MEN1KMT2APTPN11 | |
| SCHEMBL7518286 | 0.86 | EIF2AK4 (0.46) | RXFP1ALDH1A1KMT2AAKT1AKT2 | |
| SCHEMBL7522989 | 0.80 | CNR2 (0.44) | MEN1KMT2APTPN11CKS1BSKP1 | |
| SCHEMBL7514338 | 0.80 | RXFP1 (0.45) | RXFP1ALDH1A1NCF1AKT1SMO | |
| SCHEMBL7514586 | 0.78 | ITGAL (0.52) | NPSR1PTPN11NCF1SMOMAPT | |
| SCHEMBL7514841 | 0.77 | CLK1 (0.42) | RXFP1NCF1AKT1SMOMAPT | |
| SCHEMBL7519326 | 0.76 | ALDH1A1 (0.43) | RXFP1ALDH1A1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |