Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7525668 | 0.89 | ESR1 (0.33) | ESR1ESR2AR | |
| SCHEMBL7515139 | 0.79 | ESR1 (0.36) | ESR1ESR2AR | |
| SCHEMBL7526690 | 0.77 | MEN1 (0.36) | ESR1ESR2ARNR1H2NR1H3 | |
| SCHEMBL7523695 | 0.73 | AR (0.43) | ESR1ESR2AR | |
| SCHEMBL7519621 | 0.72 | ESR1 (0.33) | ESR1ESR2AR | |
| SCHEMBL8441584 | 0.72 | ESR1 (0.41) | ESR1ESR2NR1H2NR1H3 | |
| SCHEMBL7517206 | 0.70 | AR (0.37) | ESR1ESR2AR | |
| SCHEMBL8579238 | 0.69 | MEN1 (0.39) | ESR1ESR2AR | |
| SCHEMBL7518988 | 0.69 | ALOX15 (0.38) | NR1H2NR1H3 | |
| SCHEMBL7516041 | 0.69 | ALDH1A1 (0.36) | ESR1ESR2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |