Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3539509 | 0.72 | CHRNB2 (0.44) | CHRNB2CHRNA4CCNT1CDK9 | |
| SCHEMBL3539511 | 0.72 | CHRNB2 (0.44) | CHRNB2CHRNA4CCNT1CDK9 | |
| SCHEMBL2412726 | 0.68 | CHRNB2 (0.47) | CHRNB2CHRNA4CCNT1CDK9 | |
| SCHEMBL7519836 | 0.68 | LMNA (0.45) | LMNAPDE10AMAPTHPGDMEN1 | |
| SCHEMBL7965008 | 0.67 | LMNA (0.44) | LMNAPDE10AMAPTHPGDMEN1 | |
| SCHEMBL2135948 | 0.65 | LMNA (0.56) | LMNAPDE10AMAPTHPGDMEN1 | |
| SCHEMBL6214667 | 0.64 | CHRNB2 (0.55) | CHRNB2CHRNA4 | |
| SCHEMBL2881954 | 0.63 | CHRNB2 (0.67) | CHRNB2CHRNA4CCNT1CDK9 | |
| SCHEMBL12093045 | 0.63 | CHRNB2 (0.67) | CHRNB2CHRNA4CCNT1CDK9 | |
| SCHEMBL6780710 | 0.63 | CCNT1 (0.42) | CHRNB2CHRNA4MAPK1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242419-A1 | AZABICYCLO 3.2.1]OCTANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046187-A1 | AZABICYCLO[3.2.1]OCTANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |