Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838235 | 0.84 | ALDH1A1 (0.44) | HTR2CSIGMAR1MAPTALDH1A1GAA | |
| SCHEMBL7826395 | 0.81 | ALDH1A1 (0.55) | HTR2CSIGMAR1HPGDMAPTMEN1 | |
| SCHEMBL7848328 | 0.81 | PDK4 (0.44) | PDE10A | |
| SCHEMBL7837379 | 0.77 | APEX1 (0.50) | LMNAPDE10AHTR2CSIGMAR1MAPT | |
| Hydrochloric Acid SCHEMBL8708293 | 0.76 | HTR2C (0.50) | LMNAPDE10AHTR2CSIGMAR1MAPT | |
| SCHEMBL7825476 | 0.73 | SIGMAR1 (0.49) | LMNAHTR2CSIGMAR1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL8709798 | 0.72 | DRD4 (0.53) | HTR2CSIGMAR1MAPTGAARAB9A | |
| SCHEMBL1747928 | 0.72 | LMNA (0.66) | LMNAPDE10AHPGDMAPTMEN1 | |
| SCHEMBL7867866 | 0.71 | HTR2C (0.48) | HTR2CSIGMAR1MAPTALDH1A1DRD3 | |
| SCHEMBL5323553 | 0.71 | HTR2C (0.57) | HTR2CSIGMAR1MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |