Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8372598 | 0.93 | HTR1A (0.50) | HTR1AADRA2ASLC6A2SLC6A4HRH3 | |
| SCHEMBL8371199 | 0.91 | HTR1A (0.49) | HTR1AADRA2ASLC6A2SLC6A4HRH3 | |
| SCHEMBL7524469 | 0.85 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4HRH3 | |
| SCHEMBL8317904 | 0.85 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4HRH3 | |
| SCHEMBL9120164 | 0.82 | HTR1A (0.49) | HTR1AADRA2ASLC6A2SLC6A4HRH3 | |
| SCHEMBL9122214 | 0.80 | HTR1A (0.50) | HTR1AADRA2ASLC6A2SLC6A4BCL2 | |
| SCHEMBL9123531 | 0.79 | HTR1A (0.49) | HTR1AADRA2ASLC6A2SLC6A4BCL2 | |
| SCHEMBL9120347 | 0.78 | HTR1A (0.66) | HTR1AADRA2ASLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL9122514 | 0.78 | HTR1A (0.50) | HTR1AADRA2ASLC6A2SLC6A4 | |
| SCHEMBL7524073 | 0.76 | HTR1A (0.52) | HTR1AADRA2ASLC6A2SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0671397-B1 | Alkylaminoindane compounds, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-02-03 | — | — | EP | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |
| US-5569669-A | Alkylaminoindane compounds | ADIR ET COMPAGNIE (FR) | 1996-10-29 | — | — | US | disclosed |
| EP-0671397-A1 | Alkylaminoindanes compounds, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-09-13 | — | — | EP | disclosed |
| US-5389668-A | Thiochroman compounds | ADIR ET COMPAGNIE (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5385930-A | Treating central nervous system disorders like anxiety and depression | ADIR ET COMPAGNIE (FR) | 1995-01-31 | — | — | US | disclosed |
| US-5371103-A | Thiochroman compounds | ADIR ET COMPAGNIE (FR) | 1994-12-06 | — | — | US | disclosed |