Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9120347 | 0.80 | HTR1A (0.66) | HTR1AADRA2ASLC6A2SLC6A4KDM4E | |
| SCHEMBL9122214 | 0.80 | HTR1A (0.50) | HTR1AADRA2ASLC6A2SLC6A4KMT2A | |
| SCHEMBL9123531 | 0.79 | HTR1A (0.49) | HTR1AADRA2ASLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL9123010 | 0.76 | HTR1A (0.47) | HTR1AADRA2ASLC6A2SLC6A4L3MBTL1 | |
| SCHEMBL8317904 | 0.76 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7524469 | 0.76 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4KDM4E | |
| SCHEMBL7524020 | 0.76 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7522499 | 0.76 | MTNR1A (0.68) | MTNR1AMTNR1BKDM4EALDH1A1HPGD | |
| SCHEMBL8370296 | 0.76 | HTR1A (0.47) | HTR1AADRA2ASLC6A2SLC6A4KDM4E | |
| SCHEMBL8372598 | 0.75 | HTR1A (0.50) | HTR1AADRA2ASLC6A2SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |