SCHEMBL7524310

SCHEMBL7524310

CC(=O)COC(Cl)=C(C(N)=O)c1cccc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PLA2G10 O15496 1/20 0.31
GAA P10253 2/20 0.30
PRKCA P17252 1/20 0.30
GSK3B P49841 1/20 0.30
NPC1 O15118 1/20 0.30
ALDH1A1 P00352 1/20 0.30
RAB9A P51151 1/20 0.30
PTGER1 P34995 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9423043 0.76 ALDH1A1 (0.38) PLA2G10GAAGSK3BNPC1ALDH1A1
SCHEMBL27573944 0.76 ALDH1A1 (0.50) PLA2G10GAANPC1ALDH1A1RAB9A
SCHEMBL9423316 0.75 ACHE (0.43) PLA2G10GAANPC1ALDH1A1RAB9A
SCHEMBL9423186 0.74 GSK3B (0.37) PLA2G10GAAPRKCAGSK3BNPC1
SCHEMBL6465176 0.74 GAA (0.43) GAANPC1ALDH1A1RAB9ALMNA
SCHEMBL7523423 0.73
SCHEMBL7523404 0.73
SCHEMBL9423189 0.73 GAA (0.35) PLA2G10GAANPC1ALDH1A1RAB9A
SCHEMBL7526227 0.68 NOTUM (0.34) GAAALDH1A1RAB9ALMNA
SCHEMBL7524485 0.68 NOTUM (0.34) GAAALDH1A1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0770067-B1 SUBSTITUTED CINNAMIC OXIME AND HYDROXAMIDE DERIVATIVES BASF AG (DE) 2002-03-13 EP disclosed