Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524318 | 1.00 | NPC1 (0.45) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL5764963 | 0.73 | NPC1 (0.54) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL10749720 | 0.72 | NPC1 (0.53) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL5766517 | 0.70 | RAB9A (0.51) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL5766519 | 0.70 | RAB9A (0.51) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL11664761 | 0.68 | AKT1 (0.33) | HPGDALDH1A1HRH1AKT1 | |
| SCHEMBL1144315 | 0.68 | RAB9A (0.56) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL7782268 | 0.67 | NPC1 (0.62) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL8911535 | 0.66 | HPGD (0.44) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL7496643 | 0.66 | RAB9A (0.47) | NPC1RAB9AHPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940401-B1 | 2-CARBONYLTHIAZOLE DERIVATIVES AND USE OF THE SAME | TAISHO PHARMACEUTICAL CO LTD (JP) | 2002-11-06 | — | — | EP | disclosed |
| US-6166033-A | 2-carbonylthiazole derivatives and use of the same | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0940401-A1 | 2-CARBONYLTHIAZOLE DERIVATIVES AND USE OF THE SAME | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1999-09-08 | — | — | EP | disclosed |
| EP-0816362-A1 | THIAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1998-01-07 | — | — | EP | disclosed |