Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29681708 | 0.79 | KEAP1 (0.44) | GRIA2KDM4EKEAP1CA12CA1 | |
| SCHEMBL61176 | 0.79 | KEAP1 (0.44) | GRIA2KDM4EKEAP1CA12CA1 | |
| Hydrochloric Acid SCHEMBL7399331 | 0.78 | KEAP1 (0.43) | GRIA2KDM4EKEAP1CA12CA1 | |
| SCHEMBL18638475 | 0.73 | KDM4E (0.46) | GRIA2SLC40A1ALDH1A1KDM4EKEAP1 | |
| SCHEMBL22097608 | 0.73 | ALDH1A1 (0.39) | PARP1CYP3A4TSHRALDH1A1KDM4E | |
| SCHEMBL13513238 | 0.72 | TSHR (0.41) | PARP1CYP3A4TSHRALDH1A1KDM4E | |
| SCHEMBL30442903 | 0.68 | CA12 (0.47) | CYP3A4TSHRALDH1A1KDM4EHPGD | |
| SCHEMBL812924 | 0.68 | CA12 (0.47) | CYP3A4TSHRALDH1A1KDM4EHPGD | |
| SCHEMBL7522934 | 0.68 | CYP3A4 (0.38) | PARP1CYP3A4TSHRALDH1A1KDM4E | |
| SCHEMBL255918 | 0.68 | TSHR (0.50) | PARP1CYP3A4TSHRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001290-B1 | SUBSTITUTED 2,3-DIHYDROBENZ-(D)-ISOTHIAZOLE-1,1-DIOXIDES AND 2,3-DIHYDRONAPHTHO-(1,8-DE)-1,2-THIAZINE-1,1-DIOXIDES | POLAROID CORPORATION (US) | 1984-06-27 | — | — | EP | claimed |
| US-4359574-A | Thiazine-1,1-dioxide and isothiazole-1,1-dioxide derivatives | POLAROID CORPORATION (US) | 1982-11-16 | — | — | US | claimed |
| US-4311839-A | Benzisothiazole and naphtho-1,2-thiazine compounds | POLAROID CORPORATION (US) | 1982-01-19 | — | — | US | claimed |
| US-4283537-A | Thiazine-1,1-dioxide and isothiazole-1,1-dioxide derivatives and process for preparation | POLAROID CORPORATION (US) | 1981-08-11 | — | — | US | claimed |
| US-4259493-A | INDICATOR DYES OR PHOTOGRAPHIC LIGHT-SCREENING DYES | POLAROID CORPORATION (US) | 1981-03-31 | — | — | US | claimed |
| US-4259498-A | Process for preparing benzisothiazole-1,1-dioxide and naphtho-1,2-thiazine-1,1-dioxide compounds | POLAROID CORPORATION (US) | 1981-03-31 | — | — | US | claimed |
| US-4255578-A | Synthesis of perhalomethylcarbinol-substituted phenol and naphthol sulfamphthalein dyes from the corresponding triacylated derivatives | POLAROID CORPORATION (US) | 1981-03-10 | — | — | US | claimed |
| US-4210752-A | Synthesis of substituted sulfam(na)phthaleins | POLAROID CORPORATION (US) | 1980-07-01 | — | — | US | claimed |
| US-4204061-A | Sulfam(na)phthaleins | POLAROID CORPORATION (US) | 1980-05-20 | — | — | US | claimed |
| US-4195180-A | Sulfam (na) phthaleins | POLAROID CORPORATION (US) | 1980-03-25 | — | — | US | claimed |
| US-4191689-A | Benzisothiazole-1,1-dioxide and naphtho-1,2-thiazine-1,1-dioxide compounds | POLAROID CORPORATION (US) | 1980-03-04 | — | — | US | claimed |
| US-4186001-A | IRREVERSIBLE CLEAVAGE IN ALKALINE SOLUTION TO FORM COLORLESS COMPOUND | POLAROID CORPORATION (US) | 1980-01-29 | — | — | US | claimed |
| US-4178446-A | Sulfam(na)phthaleins | POLAROID CORPORATION (US) | 1979-12-11 | — | — | US | claimed |
| US-4178447-A | Novel synthesis of 3,3-substituted dihydrobenzisothiazole-1,1-dioxides and -2,3-dihydronaphtho-1,2-thiazine-1,1-dioxides | POLAROID CORPORATION (US) | 1979-12-11 | — | — | US | claimed |
| US-4139381-A | DIFFUSION TRANSFER, ANTIFOGGING AGENTS | POLAROID CORPORATION (US) | 1979-02-13 | — | — | US | claimed |
| EP-1090000-A4 | NAPHTHO 1,8-DE]THIASIN-2-YL METHYL CARBAPENEM ANTIBACTERIALS | MERCK & CO INC (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6346526-B1 | CARBAPENICILLIN WITH 1,1-DIOXO-2,3-DIHYDRONAPHTHO(1,8-DE)(1,2)THIAZIN-2-YL-SUBSTITUENT; TREATING STAPHYLOCOCCUS INFECTIONS RESISTANT TO METHICILLIN; SIDE EFFECT REDUCTION | MERCK & CO., INC. | 2002-02-12 | — | — | US | disclosed |
| EP-0001290-A1 | Substituted 2,3-dihydrobenz-(d)-isothiazole-1,1-dioxides and 2,3-dihydronaphtho-(1,8-de)-1,2-thiazine-1,1-dioxides | POLAROID CORPORATION (US) | 1979-04-04 | — | — | EP | disclosed |
| EP-0001290-A1 | Substituted 2,3-dihydrobenz-(d)-isothiazole-1,1-dioxides and 2,3-dihydronaphtho-(1,8-de)-1,2-thiazine-1,1-dioxides | POLAROID CORPORATION (US) | 1979-04-04 | — | — | EP | disclosed |
| US-4139381-A | DIFFUSION TRANSFER, ANTIFOGGING AGENTS | POLAROID CORPORATION (US) | 1979-02-13 | — | — | US | disclosed |