SCHEMBL7525213

SCHEMBL7525213

CC(=O)C(Cl)(Cl)NC(=O)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.51
HDAC3 O15379 1/20 0.47
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
IDO1 P14902 1/20 0.47
ALOX15 P16050 1/20 0.47
HDAC1 Q13547 1/20 0.47
CA9 Q16790 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HSD17B10 Q99714 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
NCOR2 Q9Y618 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
CYP2C9 P11712 2/20 0.46
LMNA P02545 2/20 0.46
EPHX1 P07099 1/20 0.46
ALDH1A1 P00352 4/20 0.44
MEN1 O00255 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10616144 0.79 HDAC3 (0.54) POLBHDAC3CA12CA1IDO1
SCHEMBL9491963 0.78 HDAC3 (0.52) POLBHDAC3CA12CA1IDO1
SCHEMBL11570784 0.76 POLB (0.50) POLBHDAC3CA12CA1IDO1
SCHEMBL408310 0.75 CYP2C9 (0.67) POLBHDAC3CA12CA1IDO1
SCHEMBL28646933 0.74 ALOX15 (0.58) POLBHDAC3CA12CA1IDO1
Acetic Acid SCHEMBL6202098 0.74 POLB (0.53) POLBHDAC3CA12CA1IDO1
SCHEMBL1233445 0.74 POLB (0.67) POLBHDAC3CA12CA1IDO1
Bromide SCHEMBL6851253 0.74 CYP2C9 (0.65) POLBHDAC3CA12CA1IDO1
Hydrochloric Acid SCHEMBL22076570 0.74 CYP2C9 (0.65) POLBHDAC3CA12CA1IDO1
SCHEMBL28820732 0.74 POLB (0.61) POLBHDAC3CA12CA1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10095757-A None JP disclosed
EP-0816328-B1 Process for the manufacture of acetonylbenzamides DOW AGROSCIENCES LLC (US) 2002-03-27 EP disclosed
EP-0816331-B1 Fungicidally active n-acetonylbenzamide compounds ROHM & HAAS (US) 2000-05-24 EP disclosed
US-5969200-A CHLORINATING PARA-TOLUOYL CHLORIDE IN PRESENCE OF CHLORINE GAS AND ALUMINUM CHLORIDE OR ANTIMONY CHLORIDE CATALYST, DISTILLING MIXTURE PRODUCED TO RECOVER 3,5-DICHLORO-4-METHYLBENZOYL CHLORIDE ROHM AND HAAS COMPANY (US) 1999-10-19 US disclosed
US-5945565-A SYNTHESIS OF 4-AMINO-3-CHLORO-5-(METHOXYIMINOMETHYL)BENZOYL CHLORIDE STARTING WITH THE CONVERSION OF 5-METHYL-4-NITRO-BENZOIC ACID TO 4-NITRO-5-(METHOXYIMINOMETHYL)-BENZOIC ACID, METHYL ESTER ROHM AND HAAS COMPANY (US) 1999-08-31 US disclosed
US-5929098-A Fungicidically active N-acetonylbenzamide compounds ROHM AND HAAS COMPANY (US) 1999-07-27 US disclosed
US-5874466-A REACTING AMINE AND ACYL CHLORIDE, HYDROGENOLYSIS ROHM AND HAAS COMPANY (US) 1999-02-23 US disclosed
JP-H1095757-A PRODUCTION OF ACETONYL BENZAMIDE ROHM & HAAS CO 1998-04-14 JP disclosed
EP-0816328-A2 Process for the manufacture of acetonylbenzamides ROHM AND HAAS COMPANY (US) 1998-01-07 EP disclosed
EP-0816331-A1 Fungicidally active n-acetonylbenzamide compounds ROHM AND HAAS COMPANY (US) 1998-01-07 EP disclosed