Pyruvate

Pyruvate

SCHEMBL7525474

CC(=O)C(=O)O.CCC1CCc2ccccc2C1=O

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.53
HTR1A P08908 2/20 0.49
SIGMAR1 Q99720 2/20 0.49
ACHE P22303 1/20 0.49
ALDH1A1 P00352 3/20 0.46
MAPT P10636 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
TP53 P04637 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
CYP26A1 O43174 1/20 0.44
KDM4E B2RXH2 1/20 0.44
TSHR P16473 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CYP27A1 Q02318 1/20 0.43
CYP24A1 Q07973 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5608451 0.89 CYP19A1 (0.59) CYP19A1HTR1ASIGMAR1ACHEALDH1A1
SCHEMBL15700140 0.80 ACHE (0.56) CYP19A1HTR1ASIGMAR1ACHEHTR2C
SCHEMBL8535642 0.79 CYP19A1 (0.58) CYP19A1HTR1ASIGMAR1ACHEALDH1A1
SCHEMBL6631961 0.77 MTNR1A (0.60) CYP19A1ALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL11734950 0.77 CYP19A1 (0.59) CYP19A1HTR1ASIGMAR1ACHEALDH1A1
SCHEMBL7672871 0.77 CYP19A1 (0.57) CYP19A1HTR1ASIGMAR1ACHEALDH1A1
SCHEMBL6630621 0.76 METAP1 (0.51) CYP19A1HTR1ASIGMAR1ACHEALDH1A1
SCHEMBL11842381 0.75 CYP19A1 (0.55) CYP19A1HTR1ASIGMAR1ACHEALDH1A1
SCHEMBL3761876 0.75 CYP19A1 (0.80) CYP19A1HTR1ASIGMAR1ACHECYP26A1
SCHEMBL28733987 0.75 CYP19A1 (0.80) CYP19A1HTR1ASIGMAR1ACHECYP26A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4732898-A HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS WARNER-LAMBERT COMPANY (US) 1988-03-22 US disclosed