Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376866 | 0.86 | HSP90AA1 (0.32) | TRPV1HSP90AA1HSP90AB1 | |
| SCHEMBL7516559 | 0.80 | CYP1A2 (0.39) | TRPV1HSP90AA1HSP90AB1GABRA1GABRB2 | |
| SCHEMBL5692015 | 0.77 | GABRA1 (0.49) | TRPV1GABRA1GABRB2MAPTCYP1A2 | |
| SCHEMBL7520561 | 0.73 | HSP90AA1 (0.37) | TRPV1HSP90AA1HSP90AB1GABRA1GABRB2 | |
| SCHEMBL7522614 | 0.73 | GABRA1 (0.40) | HSP90AA1HSP90AB1GABRA1GABRB2MAPT | |
| SCHEMBL7519181 | 0.72 | NPSR1 (0.37) | TRPV1MAPTCYP1A2CYP2D6LMNA | |
| SCHEMBL7526680 | 0.71 | ESR1 (0.39) | MAPTCYP1A2CYP2D6LMNANPSR1 | |
| SCHEMBL7521584 | 0.69 | ALOX15 (0.43) | MAPTCYP1A2CYP2D6LMNACYP3A4 | |
| SCHEMBL7521666 | 0.69 | TYR (0.44) | MAPTLMNANPSR1CYP3A4ALOX15 | |
| SCHEMBL5693094 | 0.69 | GABRA1 (0.45) | HSP90AA1HSP90AB1GABRA1GABRB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |