Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27497913 | 0.81 | GABRA1 (0.39) | HSP90AA1HSP90AB1GABRA1GABRB2MAPT | |
| SCHEMBL7519203 | 0.81 | LMNA (0.37) | HSP90AA1HSP90AB1GABRA1GABRB2LMNA | |
| SCHEMBL8580208 | 0.77 | GABRA1 (0.42) | HSP90AA1HSP90AB1GABRA1GABRB2ALDH1A1 | |
| SCHEMBL8379340 | 0.76 | CDK1 (0.33) | MAPT | |
| SCHEMBL8441756 | 0.76 | MAPT (0.38) | ALDH1A1HSD17B10MAPTLMNACYP3A4 | |
| SCHEMBL7525520 | 0.73 | TRPV1 (0.39) | HSP90AA1HSP90AB1GABRA1GABRB2ALDH1A1 | |
| SCHEMBL7526756 | 0.72 | MAPT (0.36) | ALDH1A1HTTHSD17B10MAPTNPSR1 | |
| SCHEMBL7517847 | 0.70 | MAPT (0.35) | HSP90AA1HSP90AB1ALDH1A1GAAHTT | |
| SCHEMBL7521976 | 0.69 | ESR1 (0.36) | ALDH1A1GAAHSD17B10MAPTNPSR1 | |
| SCHEMBL5157681 | 0.68 | LMNA (0.45) | HSP90AA1HSP90AB1GABRA1GABRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |