Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 12/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.58 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.58 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11628537 | 0.85 | GABRG2 (0.66) | GABRG2GABRB3GABRA5GABRA2GABRA3 | |
| SCHEMBL2841060 | 0.82 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GABRA2GABRA3 | |
| SCHEMBL30730005 | 0.80 | GABRG2 (0.77) | GABRG2GABRB3GABRA5GABRA2GABRA3 | |
| SCHEMBL7722534 | 0.78 | GABRG2 (0.75) | GABRG2GABRB3GABRA5GABRA2GABRA3 | |
| SCHEMBL9264536 | 0.77 | GABRG2 (0.57) | GABRG2GABRB3GABRA5GABRA2GABRA3 | |
| SCHEMBL6869006 | 0.75 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA2GABRA3 | |
| SCHEMBL7317652 | 0.74 | GABRA3 (0.60) | GABRG2GABRB3GABRA5GABRA2GABRA3 | |
| SCHEMBL18329262 | 0.74 | GABRG2 (0.69) | GABRG2GABRB3GABRA5GABRA2GABRA3 | |
| Ro-151310 SCHEMBL5748925 | 0.74 | GABRA1 (1.00) | GABRG2GABRB3GABRA5GABRA2GABRA3 | |
| SCHEMBL29618010 | 0.74 | GABRG2 (0.69) | GABRG2GABRB3GABRA5GABRA2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4280957-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |