Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP19 | O94966 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668667 | 0.89 | USP19 (0.46) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3902852 | 0.80 | SMN1; SMN2 (0.56) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7668679 | 0.80 | USP19 (0.46) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL8386105 | 0.79 | KMT2A (0.52) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3622805 | 0.78 | MEN1 (0.51) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL16475199 | 0.77 | TMEM97 (0.52) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL28439343 | 0.77 | MEN1 (0.50) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4391159 | 0.77 | MEN1 (0.50) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL28429223 | 0.76 | USP19 (0.55) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7524780 | 0.76 | MEN1 (0.43) | USP19SMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165013-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1165013-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6335343-B1 | IMIDAZOL-5-YLALKYLPIPERIZINE DERIVATIVES; ANTICARCINOGENIC AGENTS | MERCK & CO., INC. | 2002-01-01 | — | — | US | disclosed |
| WO-2000051547-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-09-08 | — | — | WO | disclosed |